Evidence map›Paper›PMID 40124516›Full record

ArticleiScience2025

Exploring ultraweak photon emissions as optical markers of brain activity.

Hayley Casey, Isabella DiBerardino, Mattia Bonzanni, Nicolas Rouleau, Nirosha J Murugan

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hayley CaseyDepartment of Biology, Algoma University, Sault Ste. Marie, ON P6A 2G3, Canada.
Isabella DiBerardinoDepartment of Biology, Algoma University, Sault Ste. Marie, ON P6A 2G3, Canada.
Mattia BonzanniDepartment of Neuroscience, Tufts University, Boston, MA 02111, USA.
Nicolas RouleauDepartment of Health Sciences, Wilfrid Laurier University, Waterloo, ON N2L 3C5, Canada.
Nirosha J MuruganDepartment of Biology, Algoma University, Sault Ste. Marie, ON P6A 2G3, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brains are highly metabolic organs that emit ultraweak photon emissions (UPEs), which predict oxidative stress, aging, and neurodegeneration. UPEs are triggered by neurotransmitters and biophysical stimuli, but they are also generated by cells at rest and can be passively recorded using modern photodetectors in dark environments. UPEs play a role in cell-to-cell communication, and neural cells might even have waveguiding properties that support optical channels. However, it remains uncertain whether passive light emissions can be used to infer brain states as electric and magnetic fields do for encephalography. We present evidence that brain UPEs differ from background light in spectral and entropic properties, respond dynamically to tasks and stimulation, and correlate moderately with brain rhythms. We discuss these findings in the context of other neuroimaging methods, the potential of new measurement parameters, the limitations of light-based readouts, and the possibility of developing a platform to readout functional brain states: photoencephalography.

Indexed as

Cognitive neuroscienceNeuroscience

Identifiers

PMID40124516
PMCPMC11927727

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.