Modeling zebrafish escape swim reveals maximum neuromuscular power output and efficient body movement adaptation to increased water viscosity.

Under evolutionary pressure, the kinematic and energetic characteristics of animal locomotion have been optimized for survival. We investigated the kinematics and energetic performance of zebrafish eleutheroembryo escape swims triggered by electrical stimuli in fluids of increasing viscosity. Eleutheroembryos exhibited a decrease in both tail movement frequency and swimming velocity in more viscous environments, while the amplitude of body curvature remains constant. We then combined experimental imaging of freely swimming eleutheroembryos with Navier-Stokes numerical simulations. The results showed that the mechanical power output was initially maximal and remained essentially stable with increasing viscosity, while the cost of transport was linearly correlated with viscosity. Eleutheroembryos maximize neuromuscular power output during the fast-start escape response, enabling them to potentially escape predators under all circumstances in a natural environment. This model may be used to identify genetic and toxicological factors that reduce the mechanical power developed by the neuromuscular system or induce a loss of efficiency in its use.