Evidence map›Paper›PMID 40124428›Full record

ArticleAnnals of gastroenterology

Efficacy and safety of full-thickness versus circular peroral endoscopic myotomy for treatment of achalasia: a systematic review and meta-analysis.

Sudheer Dhoop, Mohammed Abu-Rumaileh, Wasef Sayeh, Sami Ghazaleh, Conner Lombardi, Manthanbhai Patel, Bisher Sawaf, Wade Lee-Smith, Adrian Zhou, Ali Nawras and 1 more

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In one paragraph

Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sudheer DhoopDepartment of Internal Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA (Sudheer Dhoop, Mohammed Abu-Rumaileh, Manthanbhai Patel, Bisher Sawaf).
Mohammed Abu-RumailehDepartment of Internal Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA (Sudheer Dhoop, Mohammed Abu-Rumaileh, Manthanbhai Patel, Bisher Sawaf).
Wasef SayehDepartment of Gastroenterology and Hepatology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA (Wasef Sayeh, Sami Ghazaleh, Ali Nawras, Yaseen Alastal).
Sami GhazalehDepartment of Gastroenterology and Hepatology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA (Wasef Sayeh, Sami Ghazaleh, Ali Nawras, Yaseen Alastal).
Conner LombardiDepartment of Internal Medicine, University of Colorado, Denver, CO, USA (Conner Lombardi).
Manthanbhai PatelDepartment of Internal Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA (Sudheer Dhoop, Mohammed Abu-Rumaileh, Manthanbhai Patel, Bisher Sawaf).
Bisher SawafDepartment of Internal Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA (Sudheer Dhoop, Mohammed Abu-Rumaileh, Manthanbhai Patel, Bisher Sawaf).
Wade Lee-SmithUniversity Libraries, University of Toledo, Toledo, OH, USA (Wade Lee-Smith).
Adrian ZhouThe Einstein Medical Center, Philadelphia, PA, USA (Adrian Zhou).
Ali NawrasDepartment of Gastroenterology and Hepatology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA (Wasef Sayeh, Sami Ghazaleh, Ali Nawras, Yaseen Alastal).
Yaseen AlastalDepartment of Gastroenterology and Hepatology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA (Wasef Sayeh, Sami Ghazaleh, Ali Nawras, Yaseen Alastal).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Peroral endoscopic myotomy (POEM) is a treatment for esophageal achalasia with 2 variations in myotomy depth: full-thickness myotomy (FTM) and circular myotomy (CM). This systematic review and meta-analysis compares the efficacy and safety of these variations. Methods: Major health databases and registers, including Embase, MEDLINE and Cochrane were searched systematically. The primary outcome was clinical success, while secondary outcomes included change in achalasia severity scores, post-POEM gastroesophageal reflux disease (GERD) measures, procedural time, and adverse events. Meta-analysis was conducted using random-effects models, with risk ratios (RR) and mean differences (MD) calculated for dichotomous and continuous variables, respectively. Results: Nine observational studies compared FTM and CM in 1,203 patients. FTM was performed in more severe achalasia and demonstrated similar clinical success to CM (RR 1.01, 95% confidence interval [CI] 0.98-1.04; P=0.55; n=6) and procedural time (MD 3.49 min, 95%CI -2.79-9.78; P=0.28, Conclusions: FTM and CM have comparable observed clinical efficacy and procedural time, with minimal differences in complications. FTM may be preferred in more severe achalasia and its association with post-POEM GERD may have been overestimated, but it may increase post-POEM pain and LOS.

Indexed as

efficacyKeywords Peroral endoscopic myotomymyotomy depthsafety

Identifiers

PMID40124428
PMCPMC11928898

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.