Evidence map›Paper›PMID 40124403›Full record

ReviewBiophysics reviews2025

Sticking together: Polymerization of sickle hemoglobin drives the multiscale pathophysiology of sickle cell disease.

Dillon C Williams, Hannah M Szafraniec, David K Wood

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biophysics reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dillon C WilliamsDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0009-0007-6976-1712
Hannah M SzafraniecDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-8525-6990
David K WoodDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0001-5225-2144

Funding

Developing a multiscale understanding of biophysical processes in sickle cell diseaseR01HL132906 · NHLBI · UNIVERSITY OF MINNESOTA · PI WOOD, DAVID KEVIN · 2017 to 2024
$4.6M
Redefining Clinical Viscosity in Sickle Cell Diseaseby Leveraging Microfluidic TechnologiesR01HL140589 · NHLBI · EMORY UNIVERSITY · PI LAM, WILBUR A, WOOD, DAVID KEVIN · 2018 to 2021
$3.0M
NHLBI NIH HHS R01 HL132906NHLBI NIH HHS R01 HL140589
6 · The paper itself

Abstract

Sickle cell disease is a hereditary disorder in which the pathophysiology is driven by the aggregation of a mutant (sickle) hemoglobin (HbS). The self-assembly of deoxygenated sickle hemoglobin molecules into ordered fiber structures has consequences extending to the cellular and rheological levels, stiffening red blood cells and inducing pathological flow behavior. This review explores the current understanding of the molecular processes involved in the polymerization of hemoglobin in sickle cell disease and how the molecular phase transition creates quantifiable changes at the cellular and rheological scale, as well as, identifying knowledge gaps in the field that would improve our understanding of the disease and further improve treatment and management of the disease.

Identifiers

PMID40124403
PMCPMC11928100

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.