Evidence map›Paper›PMID 40124386›Full record

ArticleFrontiers in immunology2025

Intratumoral administration of

Miriam Ezcurra-Hualde, Juan Florencio Gómez-Leyva, Efren Juarez-Curiel, Yanelli Jaquelinne Regalado-Noyola, Nuria Ardaiz, Noelia Casares, David Ruiz-Guillamon, Silvia Monserrat Rodríguez-Leon, Flor Yohana Flores-Hernández, Leire Arrizabalaga and 7 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The effect of flavonoids on the doxorubicin efficacy in cancer treatment.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Miriam Ezcurra-HualdeProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.
Juan Florencio Gómez-LeyvaLaboratorio de Biología Molecular, TecNM-Instituto Tecnológico de Tlajomulco, Tlajomulco de Zúñiga, Jalisco, Mexico.
Efren Juarez-CurielProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.
Yanelli Jaquelinne Regalado-NoyolaLaboratorio de Biología Molecular, TecNM-Instituto Tecnológico de Tlajomulco, Tlajomulco de Zúñiga, Jalisco, Mexico.
Nuria ArdaizProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.
Noelia CasaresProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.
David Ruiz-GuillamonProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.
Silvia Monserrat Rodríguez-LeonEscuela de Nutrición, Universidad Autónoma de Guadalajara, Zapopan, Jalisco, Mexico.
Flor Yohana Flores-HernándezUnidad de Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, Guadalajara, Mexico.
Leire ArrizabalagaProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.
Aline RissonProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.
Román García-FuentesProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.
Celia GomarProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.
Virginia BelsueProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.
Fernando ArandaProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.
Pedro BerraondoProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.
Maritza R Garcia-GarciaProgram of Immunology and Immunotherapy, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cancer remains the leading cause of death worldwide, with increasing incidence rates. Natural compounds have gained attention as potential therapeutic agents due to their bioactive properties. Anthocyanins, particularly delphinidin-3-sambubioside (Dp-3-sam) and cyanidin-3-sambubioside (Cn-3-sam), are flavonoids with antioxidant and potential antitumor properties. This study investigates the antitumor effects of anthocyanins extracted from Methods: Anthocyanins were extracted from Results: HPLC analysis confirmed the presence of Dp-3-sam and Cn-3-sam in the Discussion: These findings highlight the potential of

Indexed as

AnthocyaninsHibiscusPlant ExtractsAnimalsAntioxidantsCell Line, TumorCell ProliferationDisease Models, AnimalFemaleHumansMiceMice, Inbred BALB CXenograft Model Antitumor AssaysAnthocyaninsAntioxidantsPlant Extractsanthocyaninsantitumor activityHibiscus sabdariffa L.immune modulationintratumoral therapy

Identifiers

PMID40124386
PMCPMC11925877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.