Evidence map›Paper›PMID 40124375›Full record

ArticleFrontiers in immunology2025

The ability to detach from biofilms in the lung airways prior to transmission to another host is associated with the infectious phenotype of

Bailey Keefe, Amy Leestemaker-Palmer, Luiz E Bermudez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bailey Keefe *Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States.
Amy Leestemaker-Palmer *Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States.
Luiz E BermudezDepartment of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States.

Funding

Mechanisms of increased susceptibility to pulmonary Nontuberculous Mycobacterial disease in the elderlyR01AI152258 · NIAID · UNIVERSITY OF KENTUCKY · PI MESSAOUDI, ILHEM · 2020 to 2024
$3.5M
NIAID NIH HHS R01 AI152258
6 · The paper itself

Abstract

Introduction: Methods: A biofilm releasing system was established. A transposon library of Results: Several enzymes and genes of unidentified function were linked with the ability to detach from the biofilm. It was also shown that detached bacteria were increased capable of establish a new biofilm, attach to epithelial cells, and infect macrophages. To determine the surface molecules linked with the ability to infect new hosts, a surface proteomic was performed, showing that detaching bacteria express many proteins do not present in biofilm bacteria. Discussion: Detached

Indexed as

BiofilmsLungMycobacterium abscessusMycobacterium Infections, NontuberculousAnimalsBacterial AdhesionBacterial ProteinsHumansMacrophagesPhenotypeProteomicsBacterial Proteinsbiofilmdetachmenthost bacterial surfaceinfectious phenotypemacrophagesmycobacterium abscessusuptake

Identifiers

PMID40124375
PMCPMC11925935

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.