Evidence map›Paper›PMID 40124360›Full record

ArticleFrontiers in immunology2025

Immune and vascular modulation by HERVs: the role of

Cristina Santos Ferreira, Alan Tardin Da Silva, Otávio José Bernandes Brustolini, Beatriz Rodrigues Pellegrina Soares, Erika Regina Manuli, Mariana Severo Ramundo, Glaucia Paranhos-Baccala, Ester Cerdeira Sabino, Ana Tereza Ribeiro Vasconcelos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cristina Santos FerreiraLaboratório de Bioinformática, Laboratório Nacional de Computação Científica (LNCC/MCTIC), Rio de Janeiro, Brazil.
Alan Tardin Da SilvaLaboratório de Bioinformática, Laboratório Nacional de Computação Científica (LNCC/MCTIC), Rio de Janeiro, Brazil.
Otávio José Bernandes BrustoliniLaboratório de Bioinformática, Laboratório Nacional de Computação Científica (LNCC/MCTIC), Rio de Janeiro, Brazil.
Beatriz Rodrigues Pellegrina SoaresDepartamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Erika Regina ManuliDepartamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Mariana Severo RamundoDepartamento de Clínica Médica, Disciplina de Imunologia Clínica e Alergia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Glaucia Paranhos-BaccalaGlobal Medical Affairs Department, bioMérieux SA, Lyon, France.
Ester Cerdeira SabinoUniversidade Municipal de São Caetano do Sul, São Caetano do Sul, Brazil.
Ana Tereza Ribeiro VasconcelosLaboratório de Bioinformática, Laboratório Nacional de Computação Científica (LNCC/MCTIC), Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Human Endogenous Retroviruses (HERVs), which can be activated by viral infections, have complex roles in gene regulation and immune modulation. However, their contribution to disease progression is not yet fully understood. Dengue fever ranges from mild symptoms to severe cases characterized by plasma leakage and immune dysregulation, providing a relevant context to investigate these interactions. Methods: This study comes up with a comprehensive analysis of differentially expressed HERVs (DE-HERVs), protein-coding genes (DEGs), and regulatory elements such as microRNAs (DE-miRNA) and non-LTR retroviruses (DE-LINEs and DE-SINEs) derived from the transcriptomes of Brazilian dengue patients across different disease stages. Results: The results show that DE-HERVs are associated with key genes identified in severe dengue cases, including Discussion: These findings improve our understanding of the molecular mechanisms underlying dengue progression and suggest that HERV-related regulatory networks may influence viral infections. Further research is required to clarify the specific roles of HERVs in dengue pathogenesis.

Indexed as

DengueEndogenous RetrovirusesReceptors, Interleukin-8ASevere DengueDengue VirusDisease ProgressionFemaleGene Expression ProfilingGene Expression RegulationHumansMicroRNAsSeverity of Illness IndexTranscriptomeMicroRNAsReceptors, Interleukin-8Adengue infectionendogenous retrovirusesHERVimmune modulationpro-inflammatory genesRNA-seq -RNA sequencingseverity progression of denguevascular leakage

Identifiers

PMID40124360
PMCPMC11925782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.