Evidence map›Paper›PMID 40124336›Full record

ArticleMaterials today. Bio2025

Tailored virus-mimicking nanoparticles mediate high transfection of pTRAIL for bystander effects in oncotherapy.

Ruirong Wu, Xiufeng Wu, Lan Zhang, Feng Zhang, Yang Ding, Yong Mao, Jiang Ni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruirong WuDepartment of Medical Oncology, Affiliated Hospital of Jiangnan University, Wuxi, 214028, China.
Xiufeng WuDepartment of Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi, 214028, China.
Lan ZhangJiangnan University Medical Center, Wuxi School of Medicine, Jiangnan University, Wuxi, 214000, China.
Feng ZhangState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, China.
Yang DingState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, China.
Yong MaoDepartment of Medical Oncology, Affiliated Hospital of Jiangnan University, Wuxi, 214028, China.
Jiang NiDepartment of Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi, 214028, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral vectors share unparalleled gene-transfection efficiency due to protein capsid-mediated target-cell recognition and efficient cellular translocation, but clinical applications are seriously hampered by potential biosafety issues. Herein, we develop a virus-mimicking nanoparticle to enable safe, selective, and efficient TRAIL-expressing plasmid (pTRAIL) transfection for site-specific apoptosis and bystander effects. For preparation, a reactive oxygen species (ROS)-responsive phenylboronic acid-rich quaternized polymer (CRP) is synthesized for electrostatic compression of pTRAIL and coordinative coupling for apolipoprotein A-I with iRGD peptide conjugation, which is termed as iaCRP/pTRAIL nanoparticles with "gene core-protein shell" structure. The tailored virus-mimicking nanoparticles could prevent pTRAIL payloads from serum elimination, accompanied by site-specific accumulation and penetration. After cellular internalization, ROS-triggered nanoparticles disassembly could further perform burst pTRAIL release and high TRAIL expression. Our findings confirm TRAIL-derived apoptosis and bystander effects, giving

Indexed as

ROS-Responsive burst releaseSafe and efficient oncotherapyTRAIL-Specific bystander effectsTumor-targeted accumulationVirus-mimicking nanoparticles

Identifiers

PMID40124336
PMCPMC11930097

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.