ArticleOphthalmology science
OCT Angiography-Derived Retinal Capillary Perfusion Measures in the Framingham Heart Study.
Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Association of epiretinal membranes with disability in people with multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Effect of Optical Coherence Tomography Angiography Image Artifacts on Quantitation of Vessel Density and Perfusion.Ophthalmic surgery, lasers & imaging retina · 2026Article
- Unsupervised quality assessment with generative adversarial networks for 3D OCTA microvascular imaging.Biomedical optics express · 2026Article
- Retinal optical coherence tomography angiography imaging in population studies for study of microvascular dysfunction in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- AI-Based Ocular Age Estimation from Combined OCT and OCTA Metrics: Decade-Stratified Normative Modelling in Healthy Eyes - a Pilot Study.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Purpose: To report baseline demographic associations and novel intereye correlations of retinal perfusion in the Framingham Heart Study (FHS). Design: Cross-sectional study. Participants: One thousand eighteen participants were recruited. Of these, 962 participants (mean age 75 ± 7, 59% female, 1720 undilated eyes) had any OCT angiography (OCTA) data. Methods: Participants from the community-based FHS were recruited between 2020 and 2022. Foveal-centered 3 × 3 mm Main Outcome Measures: Vessel skeleton density, VAD, and flux. Results: One thousand two hundred forty-four eyes (73%) had usable OCTA data with 52% acquired from the right eye. Although there was a significant correlation of retinal perfusion measures between 2 eyes of an individual, this was only moderate in magnitude (R = 0.6, Conclusions: Retinal capillary perfusion measures between 2 eyes of an individual share only moderate correlation even after adjusting for image quality and scan level artifacts. This has important implications in study design and interpretation of data from unilaterally performed studies on the retinal circulation. These data suggest that intereye differences in retinal perfusion have physiological and disease-related causes that warrant further investigation. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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Registered trials
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