Evidence map›Paper›PMID 40124162›Full record

ArticleMolecular therapy. Nucleic acids2025

Ratio of miRNA-29 to miRNA-199 expression coordinates mesenchymal stem cell repair of bleomycin-induced pulmonary injury.

Sharon J Elliot, Dustin Anderson-Terhune, Benjamin Roos, Gustavo A Rubio, Xiaomei Xia, Simone Pereira-Simon, Paola Catanuto, Gina Civettini, Emily S Hagen, Constadina Arvanitis and 2 more

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sharon J ElliotStritch School of Medicine, Department of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
Dustin Anderson-TerhuneDepartment of Pulmonary and Critical Care, University of Utah, Salt Lake City, UT 84112, USA.
Benjamin RoosStritch School of Medicine, Department of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
Gustavo A RubioAssociate Medical Director, Jackson Health System, 1611 NW 12 Avenue, Miami, FL 33136, USA.
Xiaomei XiaDepartment of Medicine, Division of Pulmonary, Critical Care, and Sleep, University of Arizona College of Medicine-Phoenix University Medical Center-Phoenix, Phoenix, AZ 85004, USA.
Simone Pereira-SimonDepartment of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33101, USA.
Paola CatanutoDepartment of Ophthalmology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33101, USA.
Gina CivettiniStritch School of Medicine, Department of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
Emily S HagenStritch School of Medicine, Department of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
Constadina ArvanitisDirector of Center for Advanced Microscopy & Nikon Imaging Center, Northwestern University, Chicago, IL 60611, USA.
Shahriar ShahzeidiGrand Health Institute, 1717 N. Bayshore Drive, Suite R244, Miami, FL 33132, USA.
Marilyn K GlassbergStritch School of Medicine, Department of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
NCI NIH HHS P30 CA060553
6 · The paper itself

Abstract

Our previous work demonstrated the anti-fibrotic effects of infusion of adipose-derived mesenchymal stem cells (ASCs) to prevent or repair bleomycin (BLM)-induced lung injury. The present study investigates mechanisms driving these anti-fibrotic effects. Pulmonary fibrosis developed at day 12 in 22-month-old C57BL/6 male mice after intratracheal BLM instillation. There was a decrease in indices of pulmonary fibrosis, including collagen content, AKT activation, collagen types I and III, α

Indexed as

mechanismsmesenchymal stem cellsmicroRNAMT: Non-coding RNAspulmonary fibrosistelomeres

Identifiers

PMID40124162
PMCPMC11930095

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.