Evidence map›Paper›PMID 40124157›Full record

ArticleSouth Asian journal of cancer2025

Practical Consensus Guidelines on the Use of Cetuximab in Head and Neck Squamous Cell Carcinoma (HNSCC).

Purvish M Parikh, Ghanashyam Biswas, Nilesh Ashok Dhamne, Chetan Dilip Deshmukh, Sewanti Limaye, Ashish Singh, Hemant Malhotra, Viashsta Pankaj Maniar, Bhupendra Nath Kapur, Prasad V S S Sripada and 13 more

Abstract read
In one paragraph

Article in South Asian journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Purvish M ParikhDepartment of Clinical Hematology, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, India.
Ghanashyam BiswasDepartment of Medical Oncology, Sparsh Hospitals and Critical Care Pvt Ltd, Bhubaneswar, Orissa, India.
Nilesh Ashok DhamneDepartment of Medical Oncology, Kolhapur Cancer Center, Kolhapur, Maharashtra, India.
Chetan Dilip DeshmukhDepartment of Medical Oncology, Deenanath Mangeskar Hospital, Pune, Maharashtra, India.
Sewanti LimayeDepartment of Medical and Precision Oncology, Sir H.N. Reliance Foundation Hospital, Mumbai, Maharashtra, India.
Ashish SinghDepartment of Medical Oncology, Christian Medical College, Vellore, Tamil Nadu, India.
Hemant MalhotraDepartment of Medical Oncology, Sri Ram Cancer Center, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, India.ORCID 0000-0001-5613-5375
Viashsta Pankaj ManiarDepartment of Medical Oncology, MOC Cancer Care and Research Center, Mumbai, Maharashtra, India.
Bhupendra Nath KapurDepartment of Medical Oncology, Yashoda Hospital, Ghaziabad, Uttar Pradesh, India.
Prasad V S S SripadaDepartment of Medical Oncology, Apollo Cancer Centers, Hyderabad, Telangana, India.
Vikas Tulsidas TalrejaDepartment of Medical Oncology, Regency Hospital, Kanpur, Uttar Pradesh, India.ORCID 0000-0002-1599-3047
Poonam PatilDepartment of Medical Oncology, Manipal Hospital, Bengaluru, Karnataka, India.ORCID 0000-0001-9518-2609
Suhas Vilasrao AgreDepartment of Medical Oncology, Hirandani Hospital, Mumbai, Maharashtra, India.
Amit Dilip BhatDepartment of Medical Oncology, Avinash Cancer Clinic, Pune, Maharashtra, India.
Priya Privadarshini NayakDepartment of Medical Oncology, Sum Ultimate Medicare, Bhubaneswar, Orissa, India.
Arun SeshachalamDepartment of Medical Oncology, Dr GVN Cancer Institute, Trichy, Kerala, India.
Boman Nariman DhabharDepartment of Medical Oncology, Fortis Mulund, Mumbai, Maharashtra, India.
Ajay SharmaDepartment of Medical Oncology, AS lifeline Cancer Care Hospital, New Delhi, India.
Niraj N BhattDepartment of Medical Oncology and Hematology, Hemato Oncology Clinic, Vadodara, Gujarat, India.
Pratap Kishore DasDepartment of Medical Oncology, Apollo Hospital, New Delhi, India.
Atul SharmaDepartment of Medical Oncology, Max Hospital Saket, New Delhi, India.
Govind Babu KanakasettyDepartment of Medical Oncology, St. Johns Medical College Hospital, Bengaluru, Karnataka, India.ORCID 0000-0002-1303-2226
Suresh Hariram AdvaniDepartment of Medical Oncology, Sushruth Hospital, Mumbai, Maharashtra, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the most common malignancy group in India and several other low- and middle-income countries. Currently, majority of the patients present in advanced stage where systemic therapy is standard of care. Multiple relapses are also not uncommon. Almost all HNSCC tumors have epidermal growth factor receptor (EGFR) overexpression, making an attractive target. Cetuximab is the most successful method to target EGFR in HNSCC. After decades of its use, it still is a prominent part of the current management guidelines. Since other agents have also been proven to be useful, we felt it was necessary to develop a real-world consensus guideline to help the decision-making process among the community oncologists. Our expert committee therefore put together currently available data, insights from their real-world clinical practice, and voted to arrive at a consensus. These consensus guidelines represent how cetuximab should be used today in the management of HNSCC.

Indexed as

EGFRmonoclonal antibodyoral cancertargeted therapy

Identifiers

PMID40124157
PMCPMC11925625

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.