ArticleIndian journal of clinical biochemistry : IJCB2025
The First-Ever Investigation of SNP rs119461977 in SECISBP2/SBP2 Gene and its Implications for Hypothyroidism: A Novel Case-Control Research.
Article in Indian journal of clinical biochemistry : IJCB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Exploring the determinants of thyroid disorders in high-altitude western Himalaya: a geospatial and epidemiological study.Journal of health, population, and nutrition · 2025Article
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4 authors.
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Abstract
Hypothyroidism is one of the most prevalent endocrine disorders worldwide. Various genes are involved in thyroid hormone production, regulation, and metabolism. SBP2 is required for the adequate assembly of selenoproteins, which are further required for thyroid hormone metabolism. Present case-control study aims to investigate the association of the K438X (rs119461977) variant situated on exon 10 of the gene with biochemical parameters and hypothyroidism. Our study comprises 253 subjects, 136 healthy control (Female 70, Male 66), and 117 case hypothyroid patients (Female 81, Male 36). Biochemical parameters were estimated using an automatic analyzer. PCR-RFLP method was used for genotyping. Heterozygous and homozygous mutant genotypes are higher among the cases as compared to control and shows significant association (
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