Evidence map›Paper›PMID 40123621›Full record

ArticleIndian journal of clinical biochemistry : IJCB2025

Serum Biomarkers and Gene Polymorphisms in COPD and COPD with T2DM Patients.

Seema Singh, Sunita Singh, Anuj Kumar Pandey, Rajeev Kumar, Santosh Kumar, Surya Kant, Ajay Kumar Verma

Abstract read
In one paragraph

Article in Indian journal of clinical biochemistry : IJCB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Seema SinghDepartment of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh 226003 India.ORCID 0000-0002-6049-3287
Sunita SinghDepartment of Microbiology, King George's Medical University, Lucknow, Uttar Pradesh 226003 India.
Anuj Kumar PandeyDepartment of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh 226003 India.ORCID 0000-0002-7403-9800
Rajeev KumarDepartment of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh 226003 India.
Santosh KumarDepartment of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh 226003 India.
Surya KantDepartment of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh 226003 India.ORCID 0000-0001-7520-5404
Ajay Kumar VermaDepartment of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh 226003 India.ORCID 0000-0002-2973-1793

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation plays an important role in chronic obstructive pulmonary disease (COPD). Increasing evidence points to the role of inflammation in the pathogenesis of type 2 diabetes mellitus (T2DM). We investigated the adiponectin: leptin and IL-8 genes in COPD-induced T2DM patients, along with the effect of polymorphism on the levels of these cytokines. We enrolled COPD, COPD plus T2DM, and healthy subjects from the institution according to standard criteria. Further, we drew a blood sample and performed genotypic analysis and an enzyme-linked immunosorbent assay (ELISA). We enrolled a total of 500 subjects in this study, including 250 controls, 191 COPD patients, and 59 COPD patients with T2DM. Genotyping of leptin (C/T), adiponectin (C/G), and IL-8 (C/T) polymorphisms was performed. Serum levels of leptin, adiponectin, and IL-8 were significantly higher (

Indexed as

Chronic obstructive pulmonary diseaseCorrelationELISAGenotypingInflammationType 2 diabetes mellitus

Identifiers

PMID40123621
PMCPMC11928340

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.