Stepwise Optimization of Traveling Wave Profiles and Inverse Gating Pattern in Structure for Lossless Ion Manipulation Platform.

Latif Mohsen, Xi Chen, Gandhi Viraj, Hua Leyan, Brian Clowers, Carlos Larriba-Andaluz

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Article in International journal of mass spectrometry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Latif MohsenMechanical Engineering Department, Purdue University, West Lafayette, IN, USA.

Xi ChenMechanical Engineering Department, Purdue University, West Lafayette, IN, USA.

Gandhi VirajMechanical Engineering Department, Purdue University, West Lafayette, IN, USA.

Hua LeyanMechanical Engineering Department, Purdue University, West Lafayette, IN, USA.

Brian ClowersDepartment of Chemistry, Washington State University, Pullman, WA, 99164, United States.

Carlos Larriba-AndaluzMechanical Engineering Department, Purdue University, West Lafayette, IN, USA.

Funding

Tractable Tandem Ion Mobility Technology using Structures for Lossless Ion Manipulations and PhotodissociationR01GM140129 · NIGMS · WASHINGTON STATE UNIVERSITY · PI CLOWERS, BRIAN · 2021 to 2024

$1.4M

NIGMS NIH HHS R01 GM140129

6 · The paper itself

Abstract

The Structure for Lossless Ion Manipulation (SLIM) platform is a powerful analytical separation tool allowing ultra-long serpentine separation path spanning hundreds of meters. In SLIM, transient fields called Traveling waves (T-wave) roll over the ions leading to separation, hence a Stepwise optimization of experimental operating conditions including amplitude, speed, and shape is essential. Here, we have characterized seven T-wave profiles including sine, triangle, square, ramp, reverse ramp, and two decreasing fields as a function of obtained resolution, resolving power and signal intensities. We found out that T-wave patterns with the most uniform electric field and least negative electric fields produce the highest resolution (reverse ramp). Both signal intensity and resolution are favorable at mid-range T-wave amplitude and speeds. The inverse gating could potentially improve the obtained resolutions as much as 35 %, in the case of reverse ramp, within 1.5 m of separation path.

Indexed as

inverse gatingIon mobility spectrometryresolution enhancementstructure for lossless ion manipulation

Identifiers

PMID40123579

DOI10.1016/j.ijms.2025.117420

PMCPMC11927961

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.