Observational studyCancer medicine2025
Association Between Treatment of Childhood Cancer and Its Late Effects on Gonadal or Growth Function in Childhood Cancer Survivors: A Retrospective Observational Study.
Observational study in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Differential effects of inspiratory muscle training on diaphragm thickness and exercise tolerance in childhood cancer survivors and non-cancer controls.Frontiers in pediatrics · 2026Article
- High prevalence of gonadal dysfunction in pediatric sarcoma survivors: insights from hormonal and clinical markers.Frontiers in pediatrics · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe late effects on childhood cancer survivors have long been recognized, but detailed studies remain limited. The current study aimed to clarify the association between childhood cancer treatment and the incidence of late effects on gonadal or growth function in Japan.
methodsThe retrospective study included medical records of patients with childhood cancer aged up to 15 years at diagnosis, who were treated with anticancer drugs at Osaka University Hospital from January 1, 2001, to December 31, 2019, and who survived at least 5 years after diagnosis. The patients' clinical background, treatment details, and anticancer drugs used were investigated. Multivariate logistic regression analysis was performed to assess the association between childhood cancer treatment and late effects on gonadal or growth function.
resultsOf the 191 eligible patients, 83 (43.5%) developed gonadal dysfunction and 38 (19.9%) developed growth dysfunction. Multivariate logistic regression analysis showed statistically significant associations of gonadal dysfunction with female sex (odds ratio [OR], 4.79; p < 0.01), autologous hematopoietic stem cell transplantation (auto-HSCT) (OR, 9.97; p < 0.01), allogeneic hematopoietic stem cell transplantation (allo-HSCT) (OR, 9.48; p < 0.01), and platinum use (OR, 4.49; p = 0.037), and of growth dysfunction with auto-HSCT (OR, 5.16; p < 0.01).
conclusionFemale sex, allo-HSCT, and use of platinum are possibly associated with an increased risk of late effects on gonadal function, while auto-HSCT may pose a risk for late effects on both gonadal and growth functions. These findings should be interpreted with caution due to the limitations of the dataset and warrant further investigation to validate these associations.
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