Evidence map›Paper›PMID 40123434›Full record

ArticleArchiv der Pharmazie2025

New benzimidazole derivatives containing hydrazone group as anticancer agents: Inhibition of carbonic anhydrase IX and molecular docking studies.

Hayrani Eren Bostancı, Mehmet Taha Yıldız, Serkan Kapancık, Zeynep Deniz Şahin Inan, Hacı Ahmet Kılıç, Özen Özensoy Güler, Ulviye Acar Çevik, Yusuf Özkay, Zafer Asım Kaplancıklı

Abstract read
In one paragraph

Article in Archiv der Pharmazie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review of promising benzimidazole-based anticancer agents (2023-2026).Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hayrani Eren BostancıDepartment of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas, Turkey.
Mehmet Taha YıldızHamidiye Faculty of Health Sciences, University of Health Sciences, Istanbul, Turkey.
Serkan KapancıkDepartment of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
Zeynep Deniz Şahin InanDepartment of Histology and Embryology, Sivas Cumhuriyet University, Sivas, Turkey.
Hacı Ahmet KılıçDepartment of Medical Biology, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey.
Özen Özensoy GülerDepartment of Medical Biology, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey.
Ulviye Acar ÇevikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.ORCID http://orcid.org/0000-0003-1879-1034
Yusuf ÖzkayDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.ORCID http://orcid.org/0000-0001-8815-153X
Zafer Asım KaplancıklıDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.ORCID http://orcid.org/0000-0003-2252-0923

Funding

None
6 · The paper itself

Abstract

In this study, we propose identifying potential novel compounds targeting carbonic anhydrase (CA) IX and anticancer activity. To study the impact of these synthesized compounds on CA IX and anticancer activity, we have developed and synthesized novel benzimidazole-hydrazone derivatives (3a-3j). The target compounds'

Indexed as

Antineoplastic AgentsBenzimidazolesCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXHydrazonesMolecular Docking SimulationAnimalsAntigens, NeoplasmCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMCF-7 CellsMiceMolecular StructureAntigens, NeoplasmAntineoplastic AgentsBenzimidazolesCA9 protein, humanCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXHydrazonesbenzimidazolecarbonic anhydrase IXflow cytometrymolecular docking

Identifiers

PMID40123434
PMCPMC11931356

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.