Evidence map›Paper›PMID 40123415›Full record

SynthesisEuropean psychiatry : the journal of the Association of European Psychiatrists2025

End-of-life care for people with severe and persistent mental illness and a life-limiting disease: An umbrella review.

Jonas Denduyver, Johan Detraux, Justien Weydts, Marc De Hert

Abstract readSystematic Review
In one paragraph

Synthesis in European psychiatry : the journal of the Association of European Psychiatrists, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Challenges in the End-of-Life Care for Patients With Severe Persistent Mental Illness: A Case Series.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jonas DenduyverUniversity Psychiatric Center Katholieke Universiteit Leuven, Kortenberg, Belgium.
Johan DetrauxUniversity Psychiatric Center Katholieke Universiteit Leuven, Kortenberg, Belgium.ORCID 0000-0002-6363-3767
Justien WeydtsUniversity Psychiatric Center Katholieke Universiteit Leuven, Kortenberg, Belgium.
Marc De HertUniversity Psychiatric Center Katholieke Universiteit Leuven, Kortenberg, Belgium.ORCID 0000-0003-4255-5920

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is widely known that people with a severe and persistent mental illness (SPMI) are more at risk of poor physical health outcomes because of disparities in healthcare access and provision. Less is known about the quality of end-of-life (EoL) care in people with SPMI who have a life-limiting disease.

methodsA comprehensive and systematic literature search in PubMed, Embase, Web of Science, Scopus, and CINAHL electronic databases (from inception to November 2023) was conducted, without language restriction, for reviews on EoL care and/or palliative sedation for people with SPMI and a life-limiting disease. A critical appraisal of the selected reviews was performed. Data were analyzed according to the four principles of biomedical ethics.

resultsTen reviews were included. These show that people with SPMI are at risk of suboptimal EoL care. Stigma among healthcare professionals, lack of integrated care policies, absence of advanced care planning, and insufficient expertise and training in palliative care of psychiatrists have been identified as key challenges to the provision of adequate EoL care for people with SPMI. No data were found about palliative sedation.

conclusionsTo optimize palliative and EoL care for SPMI patients with a life-limiting disease, a policy of coordinated and integrated mental and physical healthcare is needed. Moreover, education and training initiatives to reduce stigma and discrimination among all healthcare workers and to enhance palliative care skills in psychiatrists should be offered. Finally, more research is needed on EoL particularly on palliative sedation for people with SPMI and a life-limiting disease.

Indexed as

Mental DisordersPalliative CareTerminal CareHumansadvance care planningbipolar disorderend-of-life careintegration of careschizophreniasevere and persistent mental illnessstigma

Identifiers

PMID40123415
PMCPMC12041735

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.