Evidence map›Paper›PMID 40123351›Full record

ArticleJournal of Parkinson's disease2025

Burden of tremor in Parkinson's disease: A survey study.

Robert A Hauser, Tara Crowder Skarpaas, Andréa Merriam, Jason Rivera, Valmira Hoxhaj, Luigi M Barbato, Anita Chadha-Patel, Michelle Baladi

Abstract read
In one paragraph

Article in Journal of Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Sublingual apomorphine for Parkinsonian tremor: a post-hoc analysis of pivotal trial data.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Robert A HauserUniversity of South Florida, Tampa, FL, USA.ORCID 0000-0002-6369-1203
Tara Crowder SkarpaasJazz Pharmaceuticals, Palo Alto, CA, USA.
Andréa MerriamParkinson & Movement Disorder Alliance, Phoenix, AZ, USA.
Jason RiveraParkinson & Movement Disorder Alliance, Phoenix, AZ, USA.ORCID 0009-0008-6866-0538
Valmira HoxhajJazz Pharmaceuticals, Palo Alto, CA, USA.
Luigi M BarbatoJazz Pharmaceuticals, Palo Alto, CA, USA.ORCID 0009-0008-6574-0604
Anita Chadha-PatelACP Clinical Communications Ltd, Hertfordshire, UK.
Michelle BaladiJazz Pharmaceuticals, Palo Alto, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundTremor is reported by people with Parkinson's disease (PwP) as being one of the most troublesome symptoms.ObjectiveTo characterize the PwP experience of tremor.MethodsAn internet-based survey of PwP living with tremor was conducted in the US, from September 2023 to March 2024.ResultsSurvey responses from 634 respondents (PwP = 599; care partner = 35) were analyzed. Most (93%) PwP had tremor in their upper extremities and of these, 59% reported ≥2 tremor subtypes (rest/postural/kinetic). Overall, 24% reported little or no effect of medication and a further 25% reported that medication only somewhat improved their tremor. At least mild functional impairment due to tremor was reported by 65% of PwP and most indicated that ≥1 daily activity (83%), sensory experience (77%), or psychosocial function (92%) was impacted. Multinomial logistic regression analyses revealed that the odds [95%CI] of reporting severe functional impairment due to tremor (vs. slight) were increased by worse tremor in the dominant hand (4.9 [1.36, 17.72]); presence of OFF-time (4.7 [1.22, 18.30]), number of body parts affected (2.0 [1.45, 2.88]) and lack of medication effect (1.6 [0.30, 8.22]). The presence of all three tremor subtypes was associated with increased odds of being "

Indexed as

Activities of Daily LivingCost of IllnessParkinson DiseaseTremorAgedAged, 80 and overFemaleHumansMaleMiddle AgedUnited StatesfunctionParkinson's diseasepatient surveyquality of lifetreatmenttremor

Identifiers

PMID40123351
PMCPMC13347455

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.