Evidence map›Paper›PMID 40123296›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

The Relation Between Systemic Inflammation and the Menopause Transition: The Study of Women's Health Across the Nation.

Samar R El Khoudary, Xirun Chen, Meiyuzhen Qi, Karen A Matthews, Arun S Karlamangla, Ellen B Gold, Sioban D Harlow, Rebecca C Thurston, Hadine Joffe, Jelena Pavlovic and 1 more

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In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Samar R El KhoudaryDepartment of Epidemiology University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0003-2913-0821
Xirun ChenDepartment of Epidemiology University of Pittsburgh, Pittsburgh, PA 15260, USA.
Meiyuzhen QiDepartment of Epidemiology University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0003-0180-3588
Karen A MatthewsDepartment of Epidemiology University of Pittsburgh, Pittsburgh, PA 15260, USA.
Arun S KarlamanglaDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Ellen B GoldDepartment of Public Health Sciences, School of Medicine, University of California Davis, Davis, CA 95616, USA.
Sioban D HarlowDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48104, USA.
Rebecca C ThurstonDepartment of Epidemiology University of Pittsburgh, Pittsburgh, PA 15260, USA.
Hadine JoffeDepartment of Psychiatry, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-7035-8249
Jelena PavlovicDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Gail A GreendaleDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

Funding

The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old AgeU19AG063720 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Maria Mori Brooks · 2020 to 2026
$61.3M
WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 1994 to 2019
$37.7M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCONNELL, DANIEL S · 1994 to 2018
$18.8M
WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATTHEWS, KAREN · 1994 to 2019
$16.2M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI GOLD, ELLEN B. · 1994 to 2019
$14.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 1994 to 2018
$13.7M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 1994 to 2018
$12.9M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI KRAVITZ, HOWARD M · 1994 to 2019
$11.9M
WOMENS HEALTH ACROSS THE NATION--MASSACHUSETTS GENERAL HU01AG012531 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 1994 to 2019
$10.7M
Women's Health Across the Nation-New Jersey SiteU01AG012535 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DERBY, CAROL A. · 1994 to 2019
$9.2M
NIA NIH HHSNIH HHSNIH Office of Research on Women's Health U01AG012495NIH Office of Research on Women's Health U01AG012505NIH Office of Research on Women's Health U01AG012531NIH Office of Research on Women's Health U01AG012535NIH Office of Research on Women's Health U01AG012539NIH Office of Research on Women's Health U01AG012546NIH Office of Research on Women's Health U01AG012553NIH Office of Research on Women's Health U01AG012554NIH Office of Research on Women's Health U01NR004061NIH Office of Research on Women's Health U19AG063720NINR NIH HHSStudy of Women's Health Across the Nation
6 · The paper itself

Abstract

objectiveThe menopause transition (MT) may substantially contribute to increased systemic inflammation in later life, regardless of aging. We characterized inflammation trajectories over the MT and determined their associations with premenopausal obesity and race/ethnicity.

methodsData comprising 15 follow-up visits from Study of Women's Health Across the Nation participants who had a known date of their final menstrual period (FMP) and at least 3 measures of high-sensitivity C-reactive protein (hs-CRP) (n = 1470) or IL-6 (n = 779) were evaluated using group-based trajectory modeling and piecewise linear mixed-effects models.

resultsBased on 21 years of follow-up spanning the MT, we identified 3 trajectory groups for each inflammatory biomarker: (1) Low-Rise (hs-CRP = 27.2%; IL-6 = 36.0%); (2) Medium-Stable (hs-CRP = 41.9%) or Medium-Rise (IL-6 = 45.2%); and (3) High-Decline (hs-CRP = 30.9%) or High-Stable (IL-6 = 18.8%). The Low-Rise for both hs-CRP and IL-6 and the Medium-Rise for IL-6 trajectories showed significant increases as early as 1 year before to as late as 3 years after the FMP. The other trajectories showed either no change, or a decline around the FMP. Chinese and/or Japanese women were more likely to follow the Low-Rise hs-CRP and IL-6 trajectories, whereas Black women were more likely to follow the High-Decline hs-CRP and High-Stable IL-6 trajectories. Being overweight or obese was associated with the High-Decline hs-CRP and High-Stable IL-6 trajectories.

conclusionsMidlife women experience distinct patterns of change in hs-CRP and IL-6 over the MT. Subgroups entering the MT with low-to-medium inflammation levels, particularly for IL-6, showed rises close to the FMP, supporting a contribution of menopause in progression of systemic inflammation.

Indexed as

InflammationMenopauseWomen's HealthAdultBiomarkersC-Reactive ProteinFemaleFollow-Up StudiesHumansInterleukin-6Longitudinal StudiesMiddle AgedObesityUnited StatesBiomarkersC-Reactive ProteinIL6 protein, humanInterleukin-6C-reactive proteininflammationmenopausetrajectorywomen

Identifiers

PMID40123296
PMCPMC12527447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.