ArticleBrain and behavior2025
Neuroimaging Characteristics of Pruritus Induced by Eczema: An fMRI Study.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The Connections Between Pain and Itch: Shared Neuroimmune Mechanisms and Therapeutic Implications.Current pain and headache reports · 2026Review
- The Neuroimmune Axis in Atopic Dermatitis: From Pathogenic Mechanisms to Targeted Neuroimmunotherapy.Journal of inflammation research · 2025Review
- The immediate effect of acupuncture on brain function in patients with chronic itch: a study protocol for an fNIRS investigation.Frontiers in medicine · 2025Article
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Authors and funding
5 authors.
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Abstract
objectiveTo explore the neuroimaging characteristics of eczema-induced pruritus with resting-state functional magnetic resonance imaging (rs-fMRI).
methodsA total of 42 patients with eczema were recruited in the PE group, and 42 healthy participants were included in the HC group. The Visual Analogue Score (VAS), 12-Item Pruritus Severity Scale (12-PSS), Pittsburgh Sleep Quality Index (PSQI), and Self-Rating Anxiety Scale (SAS) were recorded in the PE group. The different values of fraction amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) were compared after rs-fMRI scanning.
resultsCompared with the HC group, the fALFF values of the left precentral gyrus, left postcentral gyrus, left supplementary motor area (SMA), and left midcingulate cortex in the PE group were increased. The FC values between the left precentral gyrus, bilateral superior temporal gyrus, bilateral hippocampus, and left inferior occipital gyrus in the PE group were decreased. The FC values between left SMA and bilateral superior temporal gyrus in the PE group were decreased. The 12-PSS score was positively correlated with fALFF value of the left precentral gyrus and left postcentral gyrus.
conclusionPruritus caused increased spontaneous activity in given cerebral regions, involving the perception of itch, control of scratching movements, and expression of itch-related emotions. Meanwhile, there is a correlation between fALFF values of given cerebral regions and clinical scales, which provided potential neurobiological markers for the future study of pruritus.
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