Evidence map›Paper›PMID 40123156›Full record

SynthesisBrain and behavior2025

Unraveling the Controversy: The Causal Link Between Osteoarthritis and Alzheimer's Disease.

Jingkai Di, Yujia Xi, Yaru Liu, Likun Qi, Tingting Chen, Shuai Chen, Chuan Xiang

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jingkai DiDepartment of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.
Yujia XiShanxi Medical University, Taiyuan, China.
Yaru LiuShanxi Medical University, Taiyuan, China.
Likun QiShanxi Medical University, Taiyuan, China.
Tingting ChenShanxi Medical University, Taiyuan, China.
Shuai ChenDepartment of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.
Chuan XiangDepartment of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.ORCID https://orcid.org/0000-0002-1121-6443

Funding

the National Natural Science Foundation of China (NSFC) and the Shanxi Provincial Health and Health Commission (SPHHC).
6 · The paper itself

Abstract

objectivesResearch on osteoarthritis (OA) and Alzheimer's disease (AD) is currently highly controversial, and the upstream and downstream relationships between them remain unclear. This study aimed to assess the association between OA and AD using Mendelian randomization (MR).

methodSummary data from genome-wide association studies (GWAS) were obtained for OA and AD. Single nucleotide polymorphisms (SNPs) were selected as instrumental variables (IVs), and significant (p < 5.0 × 10

resultsThe MR results showed a positive causal effect of AD and OA (IVW OR = 19.89, 95% CI = 2.90-136.57, p = 0.002; OR = 1.28, 95% CI = 1.11-1.47, p = 0.017; OR = 1.27, 95% CI = 1.11-1.46, p = 0.017) and no significance of the reverse MR results (p > 0.05). Meta-analysis of the MR results confirmed this finding and was significant in all population subgroups (OR = 1.29, 95% CI = 1.18-1.40). The findings were maintained after controlling confounders using MVMR (OR = 6.75, 95% CI = 1.50-30.44, p = 0.013). These analyses were confirmed to be reliable and stable by sensitivity testing.

conclusionsOur study found a positive causal effect of OA and AD, which was confirmed by the highest levels of evidence-based medicine. It may provide meaningful evidence for the current controversy.

Indexed as

Alzheimer DiseaseOsteoarthritisGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideAlzheimer's diseasecausal relationshipMendelian randomizationosteoarthritis

Identifiers

PMID40123156
PMCPMC11930851

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.