Evidence map›Paper›PMID 40123120›Full record

ArticleActa physiologica (Oxford, England)2025

Lack of renal NHE1 exacerbates lithium-induced nephrogenic diabetes insipidus.

Gabriella Blanco, Jianxiang Xue, Linto Thomas, Jessica A Dominguez Rieg, Dandan Sun, Adrienne Assmus, Robert A Fenton, Timo Rieg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Sex differences in renal acid-base regulation.American journal of physiology. Renal physiology · 2025
    Article
  3. Distinct roles of ferric carboxymaltose and ferric derisomaltose on phosphate homeostasis in iron deficiency anemia.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabriella BlancoDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Jianxiang XueDepartment of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, New Mexico, USA.
Linto ThomasDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Jessica A Dominguez RiegDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Dandan SunDepartment of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Adrienne AssmusDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Robert A FentonDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0003-1623-199X
Timo RiegDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.ORCID https://orcid.org/0000-0001-6082-662X

Funding

American Heart AssociationBLRD VA I01 BX004968Danish Council for Independent ResearchMarie Skłodowska-Curie ActionsNovo Nordisk FondenU.S. Department of Veterans Affairs
6 · The paper itself

Abstract

aimsThe sodium-hydrogen exchanger isoform 1 (NHE1) is important for transepithelial Na

methodsWe generated mice lacking NHE1 in epithelial cells throughout the kidney tubule/collecting duct (NHE1

resultsIn NHE1

conclusionLack of NHE1 interferes with the Li

Indexed as

Diabetes Insipidus, NephrogenicKidneyLithiumSodium-Hydrogen Exchanger 1AnimalsAquaporin 2MaleMiceMice, Inbred C57BLMice, KnockoutAqp2 protein, mouseAquaporin 2LithiumSlc9a1 protein, mouseSodium-Hydrogen Exchanger 1aquaporinlithiumnephrogenic diabetes insipidussodium‐hydrogen exchanger 1

Identifiers

PMID40123120
PMCPMC12924156

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.