Evidence map›Paper›PMID 40123019›Full record

ArticleCell regeneration (London, England)2025

Standard: human liver-on-a-chip.

Haitao Liu, Xu Zhang, Yaqing Wang, Min Zhang, Peng Wang, Jing Shang, Zhongqiang Li, Likun Gong, Xin Xie, Dongyang Liu and 15 more

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell regeneration (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Novel emerging cell and organoid systems for the study of drug metabolism and toxicity in humans.Drug metabolism and disposition: the biological fate of chemicals · 2025
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Haitao Liu *Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Xu Zhang *Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Yaqing WangUniversity of Science and Technology of China, Hefei, China.
Min ZhangDivision of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Peng WangUniversity of Science and Technology of China, Hefei, China.
Jing ShangChina Pharmaceutical University, Nanjing, China.
Zhongqiang LiChina National Institute of Standardization, Beijing, China.
Likun GongShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Xin XieShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Dongyang LiuPeking University Third Hospital, Beijing, China.
Jingbo PiChina Medical University, Shenyang, China.
Xinghua GaoShanghai University, Shanghai, China.
Xianliang LiDepartment of HBP Surgery, Beijing Chao Yang Hospital, the Capital Medical University, Beijing, China.
Wei DingSPH KDL Health Beijing, Shanghai Pharma, Beijing, China.
Dianbing WangInstitute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Yun LongPeking Union Medical College Hospital, Beijing, China.
Lan WangDalian Xin'en Medical Technology Co., LTD, Dalian, China.
Song LiInstitute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing, China.
Xingchao GengNational Institutes for Food and Drug Control, Beijing, China.
Pingkun ZhouInstitute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin, China.
Wanjin TangChina National Institute of Standardization, Beijing, China.
Xian'en ZhangShenzhen University of Advanced Technology, Shenzhen, China.
Chunying ChenNational Center for Nanoscience and Technology, Beijing, China.
Shengli YangDivision of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Jianhua QinDivision of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China. jhqin@dicp.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organs-on-chips are microphysiological systems designed to replicate key functions of human organs, thereby accelerating innovation in life sciences, such as disease modeling, drug development, and precision medicine. However, the lack of standardized definitions, structural designs, cell sources, model constructions, and functional validations has posed challenges to their widespread translational applications. On April 29, 2024, the Chinese Society of Biotechnology introduced "Organs-on-chips: Liver", China's first group standard for human liver-on-a-chip technology. This pioneering standard provides comprehensive guidelines, including scope, terminology, definitions, technical requirements, detection methods, and quality control measures for developing liver models on chips. The introduction of this standard is set to facilitate the establishment of institutional protocols, promote widespread adoption, and drive the international standardization of liver-on-a-chip technologies.

Indexed as

Liver-on-a-chipMicrophysiological systemOrgans-on-chipsStandard

Identifiers

PMID40123019
PMCPMC11930896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.