Evidence map›Paper›PMID 40122991›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2025

Changes in lung aeration with high-flow nasal cannula compared to nasal CPAP in preterm infants.

Anup Katheria, Felix Ines, Judith Hough, Wade Rich, Ana Morales, Shashank Sanjay, Debra Poeltler, Neil Finer

Registry-linked trialAbstract readClinical TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03700606 (Physiological Changes With High-Flow Nasal Cannula Compared to Nasal CPAP in Extremely Low Birth Weight Infants), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03700606 nacompletednot on this map

Physiological Changes With High-Flow Nasal Cannula Compared to Nasal CPAP in Extremely Low Birth Weight Infants

TypeinterventionalSponsorSharp HealthCareRan2019 to 2022Enrolled80ConditionsRespiratory Distress Syndrome in Premature InfantArmsHigh flow nasal cannula, Nasal CPAP
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anup KatheriaNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA, USA. anup.katheria@sharp.com.ORCID http://orcid.org/0000-0001-9352-0934
Felix InesNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA, USA.
Judith HoughSchool of Allied Health, Australian Catholic University, Brisbane, Australia.ORCID http://orcid.org/0000-0002-4264-9823
Wade RichNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA, USA.ORCID http://orcid.org/0000-0003-1420-9828
Ana MoralesNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA, USA.
Shashank SanjayNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA, USA.ORCID http://orcid.org/0009-0000-8069-9242
Debra PoeltlerNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA, USA.
Neil FinerNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the degree of atelectasis in preterm infants on nasal continuous airway pressure (nCPAP) versus high-flow nasal cannula (HFNC) at 8 L/min. STUDY

designA cross-over study of infants <29 weeks gestational age (GA) receiving nCPAP and underwent 6-hours of HFNC at 8 L/min before returning to nCPAP. Electrical Impedance Tomography was used to measure lung aeration.

results78 infants with median GA of 27 weeks [26, 28] were studied. HFNC was non-inferior to CPAP across the 4 periods (overall mean 2.1 ± 2.9, lower bound of confidence interval -0.9). Infants that failed HFNC had higher dependent silent spaces (DSS) measurements (1.6[0.48, 4.7] vs 0.30[0.0, 2.7], P = 0.046).

conclusionThis study of premature infants <29 weeks GA at birth demonstrated that HFNC was non-inferior to nCPAP as measured by DSS. Infants that failed HFNC had a higher percentage of DSS than those who tolerated HFNC for 6 hours suggesting decreased lung aeration. CLINICALTRIALS: gov ID: NCT03700606.

Indexed as

Continuous Positive Airway PressureLungOxygen Inhalation TherapyPulmonary AtelectasisRespiratory Distress Syndrome, NewbornCannulaCross-Over StudiesElectric ImpedanceFemaleGestational AgeHumansInfant, NewbornInfant, PrematureMaleTomography

Identifiers

PMID40122991

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.