Evidence map›Paper›PMID 40122968›Full record

ArticleInternational journal of obesity (2005)2025

Role of subclinical hypothyroidism on kidney damage in children with obesity.

Anna Di Sessa, Josè Alberto D'Anna, Rosa Melone, Gianmario Forcina, Giusy Capasso, Giuseppina Rosaria Umano, Emanuele Miraglia Del Giudice, Pierluigi Marzuillo

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Article in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Anna Di SessaDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy. anna.disessa@libero.it.ORCID 0000-0002-5877-3757
Josè Alberto D'AnnaDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Rosa MeloneDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Gianmario ForcinaDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Giusy CapassoDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Giuseppina Rosaria UmanoDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID 0000-0002-5570-6620
Emanuele Miraglia Del GiudiceDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Pierluigi MarzuilloDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID 0000-0003-4682-0170

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe interplay of subclinical hypothyroidism (SH) with obesity has been well-documented, while an intriguing but still controversial association with kidney damage (KD) has recently emerged. Given the heightened cardiometabolic risk inherent to pediatric obesity, this might further impact on the overall health of children with obesity. Therefore, we aimed at evaluating the impact of SH on KD in children with obesity. SUBJECTS/

methodsWe retrospectively examined 355 children with obesity stratified according to presence or absence of SH. KD was defined as reduced estimated glomerular filtration rate (eGFR<90 mL/min/1.73 m

resultsChildren with SH showed a higher KD prevalence than those without SH (p = 0.004). They also had lower eGFR levels than their counterparts without SH (p = 0.001) and showed an adjusted OR to have KD of 2.04 (95% CI: 1.15-3.61; p = 0.015). A general linear model for eGFR variance showed an inverse association of eGFR with TSH levels (p < 0.0001).

conclusionsAlthough preliminary, our data suggested an increased risk of KD in children with obesity and SH.

Indexed as

HypothyroidismKidney DiseasesPediatric ObesityAdolescentChildFemaleGlomerular Filtration RateHumansMaleRetrospective StudiesRisk FactorsThyrotropinThyrotropin

Identifiers

PMID40122968

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