Evidence map›Paper›PMID 40122859›Full record

ArticleCell death & disease2025

Hippocampus- and neocortex-specific deletion of Aeg-1 causes learning memory impairment and depression in mice.

Ya-He Wang, Ning Zhou, Pan-Pan Wan, Xin-Tong Li, Chun-Yang Yu, Jinjiang Chou, Zong-Yi Feng, Lian-Xiang Zhang, Juan-Juan Li, Bao-Cong Yu and 3 more

Abstract read
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ya-He WangNingxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Ning ZhouNingxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Pan-Pan WanNingxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Xin-Tong LiNingxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Chun-Yang YuNingxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Jinjiang ChouDepartment of Cell and Molecular Biology, Karolinska Institutet, Solnavägen 9, 17165, Stockholm, Sweden.
Zong-Yi FengNingxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Lian-Xiang ZhangNingxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Juan-Juan LiNingxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Bao-Cong YuNingxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Zhen-Ning TangDepartment of Surgical Oncology, General Hospital of Ningxia Medical University, 750004, Yinchuan, Ningxia, PR China. tzhn-331@163.com.ORCID http://orcid.org/0000-0002-0665-5329
Kun-Mei LiuNingxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, Yinchuan, Ningxia, 750004, China. lkm198507@126.com.ORCID http://orcid.org/0000-0002-1018-3336
Le GuoNingxia Key Laboratory of Clinical and Pathogenic Microbiology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China. Guoletian1982@163.com.ORCID http://orcid.org/0000-0001-9282-7280

Funding

National Natural Science Foundation of China (National Science Foundation of China) 3166027National Natural Science Foundation of China (National Science Foundation of China) 82160497National Natural Science Foundation of China (National Science Foundation of China) 82360711Natural Science Foundation of Ningxia Province (Ningxia Provincial Natural Science Foundation) 2022AAC02034Natural Science Foundation of Ningxia Province (Ningxia Provincial Natural Science Foundation) 2023AAC03155Natural Science Foundation of Ningxia Province (Ningxia Provincial Natural Science Foundation) 2023AAC03207
6 · The paper itself

Abstract

Astrocyte elevated gene-1 (AEG-1) has been characterized as an oncogene promoting the progression of various tumors. The role of AEG-1 in neurological diseases was highlighted by recent researches. However, the physiological function of AEG-1 remains elusive. Our study aimed to investigate the physiological role of AEG-1 in the central nervous system by generating a mouse model with specific deletion of Aeg-1 in the hippocampus and neocortex (Aeg-1

Indexed as

Cell Adhesion MoleculesDepressionHippocampusMembrane ProteinsMemory DisordersNeocortexRNA-Binding ProteinsAnimalsLearningMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsCell Adhesion MoleculesMembrane ProteinsMtdh protein, mouseRNA-Binding Proteins

Identifiers

PMID40122859
PMCPMC11930984

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.