ArticleBMC endocrine disorders2025
Menstrual disorder is associated with blood type in PCOS patients: evidence from a cross-sectional survey.
Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04264832 (Department of Traditional Chinese Medicine), which is not on this map. Not yet cited in PubMed.
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Department of Traditional Chinese Medicine (TCM), Center for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital, Beijing 100191, China.
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13 authors.
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Abstract
backgroundPrevious studies have shown a correlation between ABO blood type and the occurrence of certain diseases. However, there is limited research on the potential association between ABO blood group and polycystic ovary syndrome (PCOS). This study aims to investigate the potential connection between ABO blood type and the regularity of menstrual cycles, menstrual bleeding level, and additional metabolic indicators among individuals diagnosed with PCOS.
methodsThis cross-sectional study involved 312 PCOS patients and 133 healthy controls whose menstruation and blood type were investigated by questionnaires. Their blood lipid content and hormone levels were also measured. We assessed the association between ABO blood type distribution in different groups and the occurrence of menstrual conditions in PCOS patients.
results445 women participated in the study. There was a statistically significant difference in ABO blood type distribution among PCOS patients with varying menstrual levels (P = 0.036). Compared with other blood type groups, PCOS patients with blood type O exhibited statistically significant differences in BMI (P = 0.033), E2 levels (P < 0.001), LH levels (P = 0.022), and FSH levels (P < 0.001), and showed a higher tendency towards greater menstrual bleeding.
conclusionThere exists a correlation between ABO blood type and menstrual bleeding level among PCOS patients. In particular, individuals with blood type O display a heightened likelihood of experiencing greater menstrual bleeding with more favorable endocrine status compared to non-O blood types in the population. CLINICAL
trial registrationClinicalTrials.gov NCT04264832 ( https://clinicaltrials.gov ). Registered on February 7, 2020.
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