Evidence map›Paper›PMID 40122792›Full record

ArticleBMC cancer2025

Rehabilitation after bone marrow transplant compared with usual care to improve patient outcomes (REBOOT): protocol for a randomised controlled trial.

Linda Denehy, Shaza Abo, Christopher Swain, Camille E Short, Nicole Kiss, Amit Khot, Eric Wong, Duncan Purtill, Clare O'Donnell, Marlena Klaic and 6 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Linda DenehyDepartment of Physiotherapy, The University of Melbourne, 161 Barry Street, Parkville, VIC, 3010, Australia. l.denehy@unimelb.edu.au.
Shaza AboDepartment of Physiotherapy, The University of Melbourne, 161 Barry Street, Parkville, VIC, 3010, Australia.
Christopher SwainDepartment of Physiotherapy, The University of Melbourne, 161 Barry Street, Parkville, VIC, 3010, Australia.
Camille E ShortDepartment of Physiotherapy, The University of Melbourne, 161 Barry Street, Parkville, VIC, 3010, Australia.
Nicole KissInstitute for Physical Activity and Nutrition, Deakin University, Burwood, VIC, 3125, Australia.
Amit KhotDepartment of Oncology, Sir Peter Maccallum, University of Melbourne, Parkville, VIC, 3010, Australia.
Eric WongClinical Haematology Austin Health, 145 Studley Road, Heidelberg, VIC, 3084, Australia.
Duncan PurtillDepartment of Haematology, Fiona Stanley Hospital, Perth, WA, Australia.
Clare O'DonnellDepartment of Physiotherapy, Austin Hospital, 145 Studley Road, Heidelberg, VIC, 3084, Australia.
Marlena KlaicMelbourne School of Health Sciences, the University of Melbourne, 161 Barry Street, Parkville, VIC, 3010, Australia.
Catherine L GrangerDepartment of Physiotherapy, The University of Melbourne, 161 Barry Street, Parkville, VIC, 3010, Australia.
Michelle TewMelbourne Health Economics, Centre for Health Policy, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, 3010, Australia.
Tim SpelmanDepartment of Health Services Research, Peter Maccallum Cancer Centre, 305 Grattan Street, Melbourne, VIC, 3000, Australia.
Vinicius Cavalheri *Faculty of Health Sciences, Curtin School of Allied Health, Curtin University, GPO Box U1987, Perth, WA, 6845, Australia.
Lara Edbrooke *Department of Physiotherapy, The University of Melbourne, 161 Barry Street, Parkville, VIC, 3010, Australia.
on behalf on the REBOOT research team

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHaematological cancer affects more than 1.3 million people around the world annually and accounted for almost 800,000 deaths globally in 2020. The number of patients with these cancers undergoing bone marrow transplant is increasing. Of note, this intensive treatment is associated with complex and multifactorial side effects, often impacting nutritional status, physical functioning and overall health-related quality of life. The primary aim of this study is to investigate the effectiveness of an eight-week multidisciplinary rehabilitation intervention compared with usual care on the physical function domain of the European Organisation for the Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ-C30 version 3) in patients with haematological cancer following bone marrow transplant.

methodsThis is a multisite, pragmatic two-arm parallel-group, randomised controlled trial (RCT) with stratified randomisation, powered for superiority, recruiting 170 participants at 30 days following either allogeneic or autologous bone marrow transplant (ACTRN12622001071718). Recruitment sites include three Australian university affiliated teaching hospitals. Participants are eligible if aged ≥ 18 years, treated for haematological cancer with allogeneic or autologous bone marrow transplant and can walk independently. The intervention group will receive eight weeks of twice weekly telehealth-based exercise classes, an initial and follow up dietetics consult, post exercise protein supplements, and a home-based physical activity program, all with embedded behaviour change strategies. The primary outcome is patient reported physical function measured using the EORTC QLQ-C30 version 3. Secondary outcomes include other domains of the EORTC QLQ-C30, fatigue, physical function, physical activity levels, frailty, body composition, sarcopenia and nutrition assessment. We will also undertake a health economic analysis alongside the trial and a process evaluation exploring intervention fidelity, causal mechanisms as well as contextual influences through qualitative enquiry. DISCUSSION: The REBOOT trial will add RCT-evidence from a rigorously conducted, statistically powered multi-site trial to existing limited knowledge on the effects of multi-disciplinary rehabilitation for people with haematological cancer. If effectiveness is supported, then implementation of rehabilitation into care pathways for people having bone marrow transplant can be considered.

trial registrationACTRN12622001071718 prospectively registered 03/08/2022, last updated 08/03/2024.

Indexed as

Bone Marrow TransplantationExercise TherapyHematologic NeoplasmsAdultEquivalence Trials as TopicFemaleHumansMaleMulticenter Studies as TopicPragmatic Clinical Trials as TopicQuality of LifeRandomized Controlled Trials as TopicTreatment OutcomeBehaviour changeBone marrow transplantCancerExerciseHaematologyNutritionPhysical functionRehabilitationStem cell transplantTelehealth

Identifiers

PMID40122792
PMCPMC11931774

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.