SynthesisBMJ open2025
Risk factors for delayed graft function in patients with kidney transplantation: a systematic review and meta-analysis.
Synthesis in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Recipient-driven and donor-driven determinants of delayed graft function in paired kidney transplantation: evidence from a Chinese cohort.Renal failure · 2026Article
- Real-time Quality Assessment of Donor Kidneys During Normothermic Machine Perfusion Using Perfusate and Urinary Biomarkers.Transplantation direct · 2026Article
- Clinical outcomes of deceased donor kidney transplantation: Eight years of experience from a tertiary care center in India.World journal of nephrology · 2026Article
- Predicting delayed graft function after kidney transplant: Do complex models help compared to standard statistics?World journal of nephrology · 2026Article
- The Role of Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a Biomarker in Predicting the Function of Kidney Grafts: A Literature Review.Journal of clinical medicine · 2026Review
- The influence of recipient's pre-existing diabetes mellitus on outcomes of living donor kidney transplant.Pakistan journal of medical sciences · 2026Article
- Major Cardiovascular Complications of Index Kidney Transplantation Hospitalizations: A National Inpatient Sample Analysis.Transplantation direct · 2026Article
- Ringer Lactate Versus Hybrid Isotonic/Hypotonic Saline in Delayed Graft Function in Deceased-donor Kidney Transplantation: A Real-world Protocol Change Study.Transplantation direct · 2026Article
- Pulse Index Continuous Cardiac Output-Guided Hemodynamic Therapy in Living Donor Kidney Transplantation: A Prospective Cohort Study.Journal of clinical medicine research · 2026Article
- Review
- Delayed graft function and its impact on short- and long-term outcomes after kidney transplantation.BMC nephrology · 2026Article
- Prediction of delayed graft function after deceased donor kidney transplantation: development and temporal validation in a single-center cohort.BMC nephrology · 2026Article
- Rejection-Focused Precision Medicine in Kidney Transplantation: Biology, Biomarkers, and Artificial Intelligence.Life (Basel, Switzerland) · 2026Review
- Eligibility, timing, and organ quality: indications and outcomes of kidney transplantation in older patients.Kidney international · 2026Review
- Development and Validation of a Machine Learning-Based Nomogram for Predicting Severe Pneumocystis jirovecii Pneumonia in Kidney Transplant Recipients.Annals of transplantation · 2026Article
- Hypothermic Machine Perfusion Allows Safe Delay in Kidney Transplantation After Cold Storage.Journal of clinical medicine · 2026Article
- Predictive Value of Hematologic Inflammatory Indices for Early Dialysis Requirement After Kidney Transplantation.Annals of transplantation · 2026Article
- Challenges and outcomes in pediatric and adult kidney transplantation.Frontiers in pediatrics · 2026Review
- A Comprehensive Analysis on the Impact of Hypothermic Machine Perfusion and its Influence on Delayed Graft Function.Transplantation direct · 2025Article
- Delayed Graft Function and Its Duration as Predictors of Medium-Term Kidney Transplant Outcomes: A Retrospective Cohort Study from an Eastern European Center.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDelayed graft function (DGF) continues to represent one of the most frequently encountered early complications following kidney transplantation. Despite notable progress in donor and recipient pretreatment protocols, diagnostic techniques and therapeutic approaches, the incidence of DGF, along with its associated short- and long-term sequelae, has not demonstrated a significant reduction. DGF is influenced by a multitude of factors, and individuals with exposure to these risk factors exhibit a markedly increased probability of developing DGF.
objectivesTo systematically identify and evaluate risk factors associated with DGF in kidney transplant recipients.
designA systematic review and meta-analysis DATA SOURCES: A comprehensive search was performed across multiple databases, including PubMed, Embase, The Cochrane Library, Web of Science, CNKI, Wanfang, VIP and SinoMed, from the inception of each database until 1 March 2024. PRIMARY OUTCOME MEASURES: OR and OR 95% CI of risk factors for DGF.
resultsThe meta-analysis included 19 studies involving a total of 153 008 patients, of whom 96 596 (63.1%) developed DGF. The following risk factors for DGF were identified: prolonged cold ischaemia time (CIT) (OR=1.05, 95% CI=1.03 to 1.07, p<0.0001), elevated donor end-stage serum creatinine (OR=1.54, 95% CI=1.26 to 1.87, p<0.0001), extended dialysis vintage (OR=1.02, 95% CI=1.00 to 1.02, p=0.014), increased human leucocyte antigen (HLA) mismatch number (OR=1.19, 95% CI=1.06 to 1.33, p=0.004), higher donor body mass index (BMI) (OR=1.07, 95% CI=1.03 to 1.11, p<0.0001), advanced donor age (OR=1.02, 95% CI=1.01 to 1.03, p=0.003) and recipient diabetes mellitus (OR=1.52, 95% CI=1.40 to 1.64, p<0.0001).
conclusionThis meta-analysis identified seven significant risk factors for DGF, including prolonged CIT, elevated donor end-stage serum creatinine, extended dialysis vintage, increased HLA mismatch number, higher donor BMI, advanced donor age and recipient diabetes mellitus. These findings may offer potential insights for developing clinical strategies to mitigate the risk of DGF in kidney transplant recipients and improve postoperative management. PROSPERO REGISTRATION NUMBER: CRD42024520542.
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