Evidence map›Paper›PMID 40122464›Full record

ArticleJournal of thrombosis and haemostasis : JTH2025

Anticoagulation and other risk factors for clinically relevant bleeding after medical hospitalization: the Medical Inpatient Thrombosis and Hemostasis Study.

Mansour Gergi, Katherine Wilkinson, Andrew Sparks, Nicholas S Roetker, Hanny Al-Samkari, Nicholas L Smith, Timothy B Plante, Mary Cushman, Allen B Repp, Chris E Holmes and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mansour GergiDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA; Division of Hematology/Oncology, University of Vermont Medical Center, Burlington, Vermont, USA. Electronic address: mansour.gergi@med.uvm.edu.
Katherine WilkinsonDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA; Department of Medical Biostatistics, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Andrew SparksDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA; Department of Medical Biostatistics, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Nicholas S RoetkerChronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, Minnesota, USA.
Hanny Al-SamkariDivision of Hematology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Nicholas L SmithDepartment of Epidemiology, University of Washington, Seattle, Washington, USA; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, Washington, USA; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, Washington, USA.
Timothy B PlanteDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA; Division of Hematology/Oncology, University of Vermont Medical Center, Burlington, Vermont, USA.
Mary CushmanDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA; Division of Hematology/Oncology, University of Vermont Medical Center, Burlington, Vermont, USA; Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Allen B ReppDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA; Division of Hematology/Oncology, University of Vermont Medical Center, Burlington, Vermont, USA.
Chris E HolmesDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA; Division of Hematology/Oncology, University of Vermont Medical Center, Burlington, Vermont, USA.
Karlyn MartinDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA; Division of Hematology/Oncology, University of Vermont Medical Center, Burlington, Vermont, USA.
Neil A ZakaiDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA; Division of Hematology/Oncology, University of Vermont Medical Center, Burlington, Vermont, USA; Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.

Funding

Vermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MARY CUSHMAN, MARK T NELSON · 2020 to 2026
$17.4M
Thrombosis and Bleeding Risk Assessment in Medical InpatientsR01HL141290 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Deirdra R Terrell, Neil Adrian Zakai · 2019 to 2026
$3.5M
Antiangiogenic Therapy to Reduce Bleeding and Improve Health-Related Quality of Life in Hereditary Hemorrhagic TelangiectasiaK23HL159313 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Hanny T Al-Samkari · 2022 to 2026
$999k
NHLBI NIH HHS K23 HL159313NHLBI NIH HHS R01 HL141290NIGMS NIH HHS P20 GM135007
6 · The paper itself

Abstract

backgroundClinically relevant bleeding after discharge from a medical hospitalization is associated with increased morbidity and mortality. There is limited knowledge of the risk factors for this bleeding.

objectivesWe aimed to determine the risk factors for bleeding leading to rehospitalization after hospital discharge.

methodsThe study population consisted of primary care patients followed longitudinally from October 2010 to September 2019 for medical hospitalization and clinically relevant bleeding. People discharged alive from a medical hospitalization were followed for up to 90 days for postdischarge bleeding requiring rehospitalization. Age-, sex- (male vs female), and length of stay-adjusted hazard ratios for candidate bleeding risk factors were estimated using Cox proportional hazards models.

resultsOver 9 years, there were 15 630 medical hospitalization discharges and 414 (2.6%) postdischarge clinically relevant bleeding events that required readmission. Clinical and patient factors related to the postdischarge bleeding risk were increasing age, active cancer, liver disease, creatinine concentration of >2 g/dL, heart disease, and history of previous gastrointestinal or central nervous system bleeding. Hemoglobin concentrations of <12 g/dL for women and <13.6 g/dL for men, a platelet count of <50 × 10

conclusionPostdischarge bleeding requiring hospitalization occurs in 2.6% of medical hospitalizations and has objective and readily identifiable risk factors. Findings suggest that clinically relevant bleeding postdischarge may be predictable and quantifiable, which could help increase the safety of anticoagulation decisions at discharge.

Indexed as

AnticoagulantsBlood CoagulationHemorrhageHemostasisThrombosisAdultAgedAged, 80 and overFemaleHospitalizationHumansInpatientsLongitudinal StudiesMaleMiddle AgedPatient DischargeAnticoagulantsbleedingelectronic health recordhospitalizationrisk factors

Identifiers

PMID40122464
PMCPMC12182996

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.