Evidence map›Paper›PMID 40122439›Full record

ArticleAmerican journal of obstetrics and gynecology2025

Differences in pain regimens among nulliparous patients undergoing intrauterine device placement within a single health system.

Danielle G Tsevat, Vanessa Miller, Mia Hodges, Celia Mizelle, Julia Kessel, Gretchen Sauer, Kavita S Arora, James H Allison, Bianca A Allison

Abstract read
In one paragraph

Article in American journal of obstetrics and gynecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Danielle G TsevatDepartment of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address: Danielle_Tsevat@med.unc.edu.
Vanessa MillerDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Mia HodgesUniversity of North Carolina School of Medicine, Chapel Hill, NC.
Celia MizelleDepartment of Pediatrics, University of Colorado, Aurora, CO.
Julia KesselUniversity of North Carolina School of Medicine, Chapel Hill, NC.
Gretchen SauerDepartment of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Kavita S AroraDepartment of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
James H AllisonDepartment of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Bianca A AllisonDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
CTSA K12 Program at UNCK12TR004416 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michelle Hernandez, Jonathan J Juliano · 2023 to 2026
$6.5M
NCATS NIH HHS K12 TR004416NCATS NIH HHS UL1 TR002489NCATS NIH HHS UM1 TR004406
6 · The paper itself

Abstract

backgroundAlthough offering pain management with intrauterine device placement is recommended, but no standardized protocol exists. Patients may experience disparities pain regimens offered with placement based on where they seek care.

objectiveThis study aimed to describe the pain medication regimens that clinicians use for intrauterine device placement and the patient and clinician factors and clinic settings associated with receiving medication before and during placement. STUDY

designWe performed a retrospective study of nulliparous individuals aged 15 to 50 years who had an intrauterine device placed from 2019 to 2021 (N=1153) across a large statewide health system in the Southeast. From the electronic health record, we abstracted exposure variables (ie, patient, clinician, and clinic characteristics) and outcomes (ie, medication regimens used before and during intrauterine device placement). We used bivariate analysis and multivariable logistic regression to examine associations between exposure variables and outcomes.

resultsLess than half of the patients (41.7%) received medications before or during intrauterine device placement. Medication regimens used before and during intrauterine device placement varied by clinician specialty, clinician type, and clinic location. After multivariable regression, patients were more likely to receive preinsertion medications if they had a lower body mass index, received the Skyla intrauterine device, were treated by advanced practice providers or clinicians with a specialty in pediatrics or internal medicine, or were seen in >1 clinic visit for their intrauterine device placement (all P<.01). Patients were more likely to receive pain medications during intrauterine device placement if they were younger, treated by internal medicine clinicians, or had their intrauterine device placed on the same day they requested it, and they were less likely to receive medications during placement if seen by advanced practice providers or in a rural setting (all P<.01). There were no differences by patient race or insurance type.

conclusionWe found that pain management with intrauterine device placement is associated with clinician specialty, clinician type, and practice setting, with few significant patient factors. Although no particular pain regimen is universally recommended, several options have been shown to be potentially beneficial for nulliparous patients. Therefore, improving clinician knowledge about effective pain regimens and expanding resources across all clinic settings may improve nulliparous patients' experiences and shared decision-making regarding medication use before and during intrauterine device placement.

Indexed as

AnalgesicsIntrauterine DevicesPain ManagementPractice Patterns, Physicians'AdolescentAdultFemaleHumansMiddle AgedParityPregnancyRetrospective StudiesYoung AdultAnalgesicsdisparitiesintrauterine devicepain control

Identifiers

PMID40122439
PMCPMC12353093

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.