Evidence map›Paper›PMID 40122228›Full record

ArticleNeuroscience letters2025

Terpene blends from Cannabis sativa are cannabimimetic and antinociceptive in a mouse chronic neuropathic pain model via activation of adenosine A

Abigail M Schwarz, Caleb A Seekins, Omar El-Sissi, John M Streicher

Abstract read
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In one paragraph

Article in Neuroscience letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abigail M SchwarzDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Caleb A SeekinsDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Omar El-SissiTerpene Belt Farms, Union City, CA, USA.
John M StreicherDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA; Comprehensive Center for Pain and Addiction, University of Arizona, Tucson, AZ, USA. Electronic address: jstreicher@arizona.edu.

Funding

Therapeutic and Mechanistic Evaluation of Cannabis sativa Terpenes in Neuropathic PainR01AT011517 · NCCIH · UNIVERSITY OF ARIZONA · PI STREICHER, JOHN MICHAEL · 2021 to 2025
$1.6M
NCCIH NIH HHS R01 AT011517
6 · The paper itself

Abstract

An increase in the use of medicinal Cannabis for pain management has spurred research into the understudied bioactive compounds in Cannabis, such as terpenes. In our previous work, we showed that isolated and purified terpenes were cannabimimetic and also relieved chemotherapy-induced peripheral neuropathy (CIPN) pain via activation of Adenosine A

Indexed as

AnalgesicsCannabisChronic PainNeuralgiaReceptor, Adenosine A2ATerpenesAnimalsCannabinoidsDisease Models, AnimalFemaleMaleMicePlant ExtractsAnalgesicsCannabinoidsPlant ExtractsReceptor, Adenosine A2ATerpenesAdenosine A(2a) receptorAnalgesiaCannabimimeticCannabisNeuropathic painTerpenes

Identifiers

PMID40122228
PMCPMC12005347

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.