Evidence map›Paper›PMID 40122015›Full record

ArticleGait & posture2025

Within-session dual-task walking practice improves gait variability in older adults with multiple sclerosis.

Manuel E Hernandez, Robert W Motl, Frederick W Foley, Meltem Izzetoglu, Mark Wagshul, Roee Holtzer

Abstract read
In one paragraph

Article in Gait & posture, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Gait variability predicts falls in older adults with multiple sclerosis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Manuel E HernandezDepartment of Biomedical and Translational Sciences, Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, IL, United States; Department of Kinesiology and Community Health, College of Applied Health Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States; Neuroscience Program, College of Liberal Arts & Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States; Beckman Institute, University of Illinois Urbana-Champaign, Urbana, IL, United States.
Robert W MotlDepartment of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, United States.
Frederick W FoleyFerkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, United States; Multiple Sclerosis Center, Holy Name Medical Center, Teaneck, NJ, United States.
Meltem IzzetogluVillanova University, Electrical and Computer Engineering, Villanova, PA, United States.
Mark WagshulDepartment of Radiology, Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States.
Roee HoltzerFerkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, United States; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, United States. Electronic address: roee.holtzer@einsteinmed.edu.

Funding

Brain Predictors of Mobility and Falls in Older Adults with Multiple SclerosisR01NS109023 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI HOLTZER, ROEE · 2019 to 2023
$3.4M
NINDS NIH HHS R01 NS109023
6 · The paper itself

Abstract

backgroundGreater gait variability is associated with falls in aging and multiple sclerosis. However, whether older adults with MS (OAMS), show higher gait variability relative to healthy older adults (HOA), under single and dual-task walking conditions, has not been reported. Furthermore, it is unclear whether practice may improve gait variability in both groups. RESEARCH QUESTION: Is gait variability higher in OAMS relative to HOA, particularly in DTW compared to STW? Furthermore, does practice result in decreased gait variability in both groups, notably under DTW compared to STW?

methodsWe examined the effect of within-session practice on gait variability during single (STW) and dual (DTW) task gait conditions. OAMS (n = 97, mean±SD age: 65 ± 5 years, 66 females) and HOA (n = 113, mean±SD age: 68 ± 7 years, 73 females) were recruited. Practice effects on gait variability were evaluated over three repeated counterbalanced STW and DTW trials. Gait variability measures included Coefficient of Variation (CV) in stride velocity, stride length, and swing time.

resultsOAMS demonstrated higher gait variability, on all measures, relative to HOA during both STW and DTW (P < 0.001). Gait variability on all measures was higher in DTW compared to STW, (P < 0.05). Practice resulted in decreased gait variability (P < 0.01) on all measures in both OAMS and HOA. Furthermore, practice resulted in decreased temporal gait variability, as measured by swing time CV, under DTW in particular (P < 0.05). SIGNIFICANCE: In conclusion, OAMS exhibited greater gait variability than HOA, yet both groups demonstrated decreases in temporal and spatial gait variability after within-session practice, notably under DTW, which in turn may reduce fall risk.

Indexed as

GaitGait Disorders, NeurologicMultiple SclerosisPractice, PsychologicalWalkingAccidental FallsAgedBiomechanical PhenomenaFemaleGait AnalysisHumansMaleMiddle AgedAgingDual-task walkingGait variabilityMultiple sclerosis

Identifiers

PMID40122015
PMCPMC12048238

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.