ArticleThe journal of nutrition, health & aging2025
Intrinsic capacity in patients with dementia with Lewy bodies compared with those with Alzheimer's disease: A cross-sectional study.
Article in The journal of nutrition, health & aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Multiple chronic conditions and intrinsic capacity among middle-aged and older adults: Evidence from CHARLS.Medicine · 2026Article
- Association of Changes in Intrinsic Capacity With Cognitive Decline and Dementia: A Prospective Cohort Study.Neurology · 2026Article
- Dual trajectories of intrinsic capacity and frailty: a joint predictor framework for dementia risk in middle-aged and older adults.BMC public health · 2026Article
- Associations between frailty, biomarkers of cerebral pathology, cognitive and neuropsychiatric symptoms: a memory clinic study.The Journal of frailty & aging · 2026Article
- Simultaneous perfusion and dopaminergic imaging using dual-isotope CZT SPECT/CT in dementia with Lewy bodies.EJNMMI research · 2026Article
- Article
- Intrinsic capacity in Lewy body dementia: a review.The Journal of frailty & aging · 2025Review
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9 authors.
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Abstract
objectivesIntrinsic capacity (IC), the composite of all the physical and mental capacities of an individual, has never been studied in patients with dementia with Lewy bodies (DLB). As IC decline is associated with the risk of frailty, functional decline and disability and is potentially reversible after targeted interventions, a monitoring and specific management of IC decline in patients with DLB could promote healthy aging in this population. The aim of this cross-sectional study was to describe the frequency of IC decline in DLB and to compare it with AD.
designA single-center cross-sectional study.
settingThis study was carried out in a memory clinic between 2015 and 2023 based on the MEMORA cohort.
participantsPatients with a diagnosis of AD or probable DLB and a comprehensive geriatric assessment. MEASUREMENTS: IC was assessed according to the WHO model in 4 domains: vitality assessed by the Mini Nutritional Assessment (MNA), locomotion assessed by the Short Physical Performance Battery (SPPB), psychology assessed by the Geriatric Depression Scale 4-items (GDS-4 items), and hearing assessed by the Hearing, Vision, Equilibrium and Cognition (HVEC) scale.
resultsA total of 798 patients (154 with probable DLB and 644 with AD) were included, and the mean age was 81.4 years (SD 6.33). Compared with AD patients, DLB patients had significantly more impaired IC in all domains, with greater risks of impaired vitality (odds ratio (OR) 2.43, 95% confidence interval (CI) 1.60-3.72), locomotion (OR 3.50, 95% CI 2.15-5.90), psychology (OR 2.60, 95% CI 1.73-3.92) and hearing (OR 2.30, 95% CI 1.53-3.49), according to the adjusted models. Similarly, when IC domains were considered linear variables, IC across all domains was significantly lower in the DLB group than in the AD group.
conclusionThis study revealed that DLB patients presented a greater decrease in IC than did AD patients across all domains. In memory clinics, DLB patients could be offered systematic and early IC monitoring and personalized interventions.
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