Evidence map›Paper›PMID 40121608›Full record

ArticleTechniques in coloproctology2025

Oral antimicrobial prophylaxis was associated with preventing surgical site infection following 2-stage restorative proctocolectomy in patients with ulcerative colitis.

Y Horio, M Uchino, Y Tomoo, K Nomura, K Nagano, K Kusunoki, R Kuwahara, K Kimura, K Kataoka, N Beppu and 5 more

Abstract read
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In one paragraph

Article in Techniques in coloproctology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Y HorioDepartment of Gastroenterological Surgery, Hyogo Medical University, 1-1, Mukogawa-Cho, Nishinomiya, Hyogo, 663-8501, Japan. yu-horio@hyo-med.ac.jp.
M UchinoDepartment of Gastroenterological Surgery, Hyogo Medical University, 1-1, Mukogawa-Cho, Nishinomiya, Hyogo, 663-8501, Japan.
Y TomooDepartment of Gastroenterological Surgery, Hyogo Medical University, 1-1, Mukogawa-Cho, Nishinomiya, Hyogo, 663-8501, Japan.
K NomuraDepartment of Gastroenterological Surgery, Hyogo Medical University, 1-1, Mukogawa-Cho, Nishinomiya, Hyogo, 663-8501, Japan.
K NaganoDepartment of Gastroenterological Surgery, Hyogo Medical University, 1-1, Mukogawa-Cho, Nishinomiya, Hyogo, 663-8501, Japan.
K KusunokiDepartment of Gastroenterological Surgery, Hyogo Medical University, 1-1, Mukogawa-Cho, Nishinomiya, Hyogo, 663-8501, Japan.
R KuwaharaDepartment of Gastroenterological Surgery, Hyogo Medical University, 1-1, Mukogawa-Cho, Nishinomiya, Hyogo, 663-8501, Japan.
K KimuraDepartment of Gastroenterological Surgery, Hyogo Medical University, 1-1, Mukogawa-Cho, Nishinomiya, Hyogo, 663-8501, Japan.
K KataokaDepartment of Gastroenterological Surgery, Hyogo Medical University, 1-1, Mukogawa-Cho, Nishinomiya, Hyogo, 663-8501, Japan.
N BeppuDepartment of Gastroenterological Surgery, Hyogo Medical University, 1-1, Mukogawa-Cho, Nishinomiya, Hyogo, 663-8501, Japan.
T UedaDepartment of Infection Control and Prevention, Hyogo Medical University, Nishinomiya, Hyogo, 663-8501, Japan.
K IchikiDepartment of Infection Control and Prevention, Hyogo Medical University, Nishinomiya, Hyogo, 663-8501, Japan.
K NakajimaDepartment of Infection Control and Prevention, Hyogo Medical University, Nishinomiya, Hyogo, 663-8501, Japan.
M IkedaDepartment of Gastroenterological Surgery, Hyogo Medical University, 1-1, Mukogawa-Cho, Nishinomiya, Hyogo, 663-8501, Japan.
H IkeuchiDepartment of Gastroenterological Surgery, Hyogo Medical University, 1-1, Mukogawa-Cho, Nishinomiya, Hyogo, 663-8501, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurgical site infection (SSI) is a critical issue in colorectal surgery because it decreases postoperative patient quality of life. The rate of SSI in patients with ulcerative colitis (UC) receiving immunosuppressive therapy is particularly high, suggesting that the SSI rate may increase with the introduction of biologic agents.

methodsUC patients who underwent two-stage restorative proctocolectomy at our institution between April 2012 and December 2023 were included in this study. Clinical characteristics were analyzed and compared between an SSI group and a non-SSI group; possible risk factors for SSIs were also analyzed. Additionally, the following anti-SSI measures adopted at our hospital were included as explanatory variables: laparoscopic surgery, oral antibiotic prophylaxis and change of surgical instruments before wound closure.

resultsIn total, 501 UC surgical patients were included. The incidence of overall SSIs was 45/501 (8.9%). The rates of incisional SSIs and organ/space SSIs were 26/501 (5.1%) and 30/501 (5.9%), respectively. Oral antibiotic prophylaxis was identified as a risk factor for overall SSIs (odds ratio: 0.45, 95% CI 0.20-0.99, p = 0.02), incisional SSIs (odds ratio: 0.34, 95% CI 0.11-1.03, p = 0.03) and organ/space SSIs (odds ratio: 0.35, 95% CI 0.12-0.98, p = 0.04). The use of biologic and immunosuppressive agents was not associated with any SSIs.

conclusionsNonadministration of oral antibiotic prophylaxis was identified as a risk factor for SSIs. Oral antibiotic prophylaxis before restorative proctocolectomy may improve the postoperative quality of life of UC patients by preventing SSIs.

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisColitis, UlcerativeProctocolectomy, RestorativeSurgical Wound InfectionAdministration, OralAdultFemaleHumansIncidenceMaleMiddle AgedQuality of LifeRetrospective StudiesRisk FactorsYoung AdultAnti-Bacterial AgentsOral antibiotic prophylaxisPostoperative complicationsRestorative proctocolectomySurgical site infectionUlcerative colitis

Identifiers

PMID40121608
PMCPMC11930863

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