Observational studyClinical pharmacokinetics2025
Volume Kinetics of Gelofusine 4% During Vascular Surgery.
Observational study in Clinical pharmacokinetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06474052 (Volume Kinetics of Gelofusine 4% During Uncomplicated Vascular Surgery), which is not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Volume Kinetics of Gelofusine 4% During Uncomplicated Vascular Surgery
Who cites it
5 citing papers in PubMed.
- Acute myocardial mechanical responses to colloid and crystalloid volume loading: A randomized double-blind crossover study.British journal of clinical pharmacology · 2026Trial
- Gelatin 4% and hydroxyethyl starch (130/0.42) impair clot formation in a human ex vivo whole-blood resuscitation model.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Article
- Albumin 20% in surgical and critically ill patients; a comprehensive review.Critical care (London, England) · 2026Review
- When does the "third fluid space" open?Pflugers Archiv : European journal of physiology · 2025Article
- Attenuation of the plasma volume response to crystalloid fluid used for goal-directed fluid therapy.Annals of intensive care · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe volume kinetics of a commercially available colloid fluid, Gelofusine, have not been studied previously.
methodsIntravenous Gelofusine 10 mL/kg was infused over 30 min in 15 patients undergoing vascular surgery. Of the 15 patients, 14 were classified as American Society of Anesthesiologists (ASA) class III status. The distribution and elimination of the infused volume was calculated with mixed-model kinetics based on 280 measurements of the hemoglobin-derived plasma dilution (19 per patient) collected over 180 min.
resultsThe expanded central fluid space volume (V
conclusionThe kinetics of Gelofusine was predictable in patients of American Society of Anesthesiologists class III status undergoing vascular surgery, with the fluid expanding the vascular space and the half-life shortened by noradrenaline.
trial registrationRetrospectively registered with ClinicalTrials.gov NCT06474052, June 24, 2024.
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Registered trials
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