ArticleEuropean radiology experimental2025
Photon-counting versus energy-integrating CT of abdomen-pelvis: a phantom study on the potential for reducing iodine contrast media.
Article in European radiology experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Photon-counting CT in head and neck radiology: bridging detector physics and clinical applications.European radiology · 2026Review
- Understanding Photon-Counting CT: Physics, Detector Technology, and Image Reconstructions.Sensors (Basel, Switzerland) · 2026Review
- Photon counting detector CT contrast agent-reduced transcatheter aortic valve reconstruction planning: a comparative study.European radiology · 2026Article
- A Practical Rule-of-Thumb to Adapt Contrast Media Dose in Photon-counting Detector CT: The 10-to-5 Rule.Investigative radiology · 2026Article
- Optimization of hypovascular liver lesion detectability in dual-energy CT using deep learning image reconstruction: a phantom study for potential iodine dose reduction.European radiology experimental · 2026Article
- Photon-counting computed tomography enables low-dose, high-quality abdominal imaging: A comparative study with energy-integrating detector computed tomography.World journal of radiology · 2026Article
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Abstract
backgroundTo assess the potential of virtual monoenergetic images (VMIs) on a photon-counting computed tomography (PCCT) for reducing the amount of injected iodine contrast media compared to an energy-integrating CT (EICT).
methodsA multienergy phantom was scanned with a PCCT and EICT at 11 mGy with abdomen-pelvis examination parameters. VMIs were generated at 40 keV, 50 keV, 60 keV, and 70 keV. For all VMIs, the contrast-to-noise ratio (CNR) of iodine inserts with concentrations of 1 mg/mL, 2 mg/mL, 5 mg/mL, 10 mg/mL, and 15 mg/mL was calculated by dividing the signal difference between HU in iodine inserts versus solid water by the noise value assessed on solid water. The potential reduction in iodine media was calculated by the rate of reduction in iodine concentration with PCCT while maintaining the same CNR obtained with EICT for the reference concentration.
resultsSignificantly higher CNR values were found with PCCT at all VMI energy levels for iodine concentrations above 1 mg/mL. The highest reduction was observed at 40 keV, with a value of 48.9 ± 1.6% (mean ± standard deviation). It decreased as the energy level increased, by 38.5 ± 0.5%, and 30.8 ± 0.8% for 50 and 60 keV, respectively. For 70 keV, the potential reduction of 24.4 ± 1.1% was found for iodine concentrations above 1 mg/mL. This reduction reached 57 ± 2.3% at 40 keV with PCCT compared to 60 keV with EICT.
conclusionFor abdomen-pelvis protocols, the use of VMIs with PCCT significantly improved the CNR of iodine, offering the potential to reduce the required contrast medium. RELEVANCE STATEMENT: The use of VMIs with PCCT may reduce the quantity of iodine contrast medium to be injected compared with EICT, limiting costs, the risk of adverse effects, and the amount of contrast agent released into the wastewater. KEY POINTS: PCCT improves the image quality of VMIs. PCCT offers the potential for reducing the amount of injected contrast medium. PCCT potential for reducing the injected contrast medium depends on energy level.
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