ArticleSleep2025
Enhancement of glymphatic function and cognition in chronic insomnia using low-frequency rTMS.
Article in Sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Article
- Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets.Molecular biomedicine · 2026Review
- Assessment of glymphatic system function using DTI-ALPS in depressive disorders: a study of its correlation with clinical features and plasma GFAP levels.Quantitative imaging in medicine and surgery · 2026Article
- Developmental Alterations in the Diffusion Tensor Imaging Analysis Along the Perivascular Space Index Suggest Possible Glymphatic-Related Mechanisms Underlying Excitation/Inhibition Imbalance and Psychosis Vulnerability in 22q11.2 Deletion Syndrome.Biological psychiatry global open science · 2026Article
- Major neurocognitive impairment among Elders in Southwest Ethiopia community based cross sectional study.Discover mental health · 2026Article
- Potential role of meningeal lymphatic drainage in repetitive transcranial magnetic stimulation-induced cognitive improvement: A call for further research.World journal of psychiatry · 2025Article
- Neuroprotective effects of rTMS in chronic insomnia: is glymphatic system modulation the key player?Sleep · 2025Article
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10 authors.
Funding
Abstract
STUDY
objectivesLow-frequency repetitive transcranial magnetic stimulation (LF-rTMS) is a promising treatment for chronic insomnia; however, its effectiveness in improving cognitive and glymphatic clearance functions remains unclear. We aimed to investigate the effects of chronic insomnia on glymphatic clearance function and the effectiveness of LF-rTMS on chronic insomnia.
methodsThirty-two patients with chronic insomnia and 40 healthy controls underwent baseline assessments of clinical measures and glymphatic functions using diffusion tensor imaging analysis along the perivascular space (DTI-ALPS). Thereafter, 22 patients underwent 10 sessions of LF-rTMS over two consecutive weeks, sleep assessments at week 2 and months 1, 2, and 3, and DTI-ALPS and cognitive-related assessments at week 2 and month 3.
resultsCompared to healthy controls, patients showed significant differences in the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Montreal Cognitive Assessment (MoCA) Scale, digit symbol substitution test (DSST), color trail test (CTT), digit span test (DST), Stroop tests, and DTI-ALPS index (all ps < 0.05). After LF-rTMS, patients showed a significant decrease in PSQI and ISI scores from week 2 onwards and significant improvement in MoCA, DSST, DST, CTT-B tests, and DTI-ALPS index by month 3 (all ps < 0.05). Furthermore, the increase in the DTI-ALPS index was significantly associated with improvements in PSQI, ISI, MoCA, and DST-backward at month 3 (r = 0.579, 0.558, 0.836, and 0.642, respectively, and p = 0.038, 0.047, <0.001, and 0.018, respectively).
conclusionsThis study provided preliminary evidence for LF-rTMS' valuable effects on glymphatic clearance and cognitive function in patients with chronic insomnia, which supports LF-rTMS' clinical application in those population. CLINICAL TRIAL INFORMATION: This study has been officially registered with the Chinese Clinical Trial Registry. The trial, titled "Effect of Repetitive Transcranial Magnetic Stimulation for the Treatment of Chronic Insomnia and the Underlying Brain Mechanism," is accessible via the following URL: https://www.chictr.org.cn/showproj.html?proj=205347. The registration number assigned to this trial is ChiCTR2300077939.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.