ArticleCardiovascular diabetology2025
Impact of glycemic control metrics on short- and long-term mortality in transcatheter aortic valve replacement patients: a retrospective cohort study from the MIMIC-IV database.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictive value of different glycemic variability indicators for prognosis in critically ill patients: a meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Early ICU glycemic trajectory phenotypes predict short- and long-term mortality in critically ill patients: a dual-database cohort study.Metabolism open · 2026Article
- Shared pathophysiological mechanisms between diabetes and calcific aortic valve disease: an immunometabolic perspective.Cardiovascular diabetology · 2026Review
- Cumulative stress hyperglycemia ratio exposure and dynamic trajectories reveal prognostic determinants of acute hyperlipidemic pancreatitis: an 5-year cohort study.Lipids in health and disease · 2026Article
- Prognostic value of stress hyperglycemia ratio, hemoglobin glycation index, and glycemic variability for postoperative atrial fibrillation: a machine learning-based prediction model.BMC medical informatics and decision making · 2026Article
- Research on the author collaboration network and institutional influence in the transcatheter aortic valve replacement field based on CiteSpace: analysis of the top one hundred highly cited articles.Journal of cardiothoracic surgery · 2026Article
- Influencing factors and predictive model construction of perioperative blood glucose fluctuations in patients with coronary heart disease complicated with type 2 diabetes mellitus undergoing percutaneous coronary intervention.BMC endocrine disorders · 2026Article
- Prognostic performance of clinical scores and biomarkers in nonagenarians after TAVR requiring ICU admission.Scientific reports · 2026Article
- Association between hemoglobin glycation index and all-cause mortality in patients with non-ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention.Frontiers in endocrinology · 2026Article
- Article
- Prognostic value of the AIP index in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement.Frontiers in nutrition · 2026Article
- Predicting mortality in non-traumatic intracerebral hemorrhage with glucose and lipid data.Frontiers in endocrinology · 2026Article
- Glycemic variability and postoperative mortality following cardiac surgery: evidence from a real-world ICU cohort.BMC cardiovascular disorders · 2025Observational
- Differential prognostic value of glycemic dysregulation markers in critically ill individuals with ischemic stroke, with and without diabetes.Diabetology & metabolic syndrome · 2025Article
- Combined assessment of stress hyperglycemia ratio and glycemic variability to predict all-cause mortality in critically ill patients with atherosclerotic cardiovascular diseases across different glucose metabolic states: an observational cohort study with machine learning.Cardiovascular diabetology · 2025Observational
- Correlation of triglyceride-glucose index with the incidence and prognosis of hyperglycemic crises in critically ill patients with diabetes mellitus: a machine-learning-based multicenter retrospective cohort study.Frontiers in nutrition · 2025Article
- Association between the postoperative glycemic variability and mortality after craniotomy: a retrospective cohort study and development of a mortality prediction model.Frontiers in endocrinology · 2025Article
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Abstract
backgroundGlycemic control is critical for managing transcatheter aortic valve replacement (TAVR) patients, especially those in intensive care units (ICUs). Emerging metrics such as the hemoglobin glycation index (HGI), stress hyperglycemia ratio (SHR), and glycemic variability (GV) offer advanced insights into glucose metabolism. However, their prognostic implications for short- and long-term outcomes post-TAVR remain underexplored.
methodsThis retrospective cohort study analyzed 3342 ICU-admitted TAVR patients via the MIMIC-IV database. Patients were stratified into tertiles for HGI, SHR, and GV levels. Survival analyses, including Kaplan‒Meier curves, Cox proportional hazards models and restricted cubic splines (RCSs), were used to assess associations between glycemic control metrics and 30-day and 365-day all-cause mortality in these patients. Sensitivity analyses, subgroup assessments, and external validation were also performed to verify the study findings.
resultsDuring follow-up, 1.6% and 6.9% of patients experienced 30-day and 365-day mortality after TAVR, respectively. In the fully adjusted cox regression model, lower HGI (HR 1.48, 95% CI 1.05-2.09, P = 0.025) and higher SHR (HR 1.63, 95% CI 1.15-2.32, P = 0.006) were most significantly associated with an increased risk of 365-day mortality. Higher SHR was also significantly associated with an increased risk of 30-day mortality in patients (HR 2.92, 95% CI 1.32-6.45, P = 0.008). Both lower (HR 0.59, 95% CI 0.38-0.92, P = 0.019) and higher GV levels (HR 1.43, 95% CI 1.06-1.93, P = 0.020) were associated with the risk of 365-day mortality.
conclusionsIn critically ill TAVR patients, glycemic control metrics are closely associated with long-term all-cause mortality. The HGI, SHR, and GV provide prognostic insights into clinical outcomes that surpass conventional glucose measurements. These findings highlight the importance of personalized glycemic management strategies in improving TAVR patient outcomes.
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