ArticleEye (London, England)2025
Causal effects of allergic diseases on the risk of myopia: a two-sample Mendelian randomization study.
Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Changes in Ocular Biomechanics During Adolescence and Its Relationship with Lifestyle and Myopic Progression: The Oporto Myopia Study.Bioengineering (Basel, Switzerland) · 2026Article
- A TabPFN-based prediction system for refractive error and dry eye comorbidity: a retrospective study using large-scale real-world data.Frontiers in cell and developmental biology · 2026Article
- Mendelian randomization studies in atopic dermatitis: causal insights across omics layers.Frontiers in immunology · 2026Review
- Choroidal Mast Cells and Their Degranulation Are a Pivotal Trigger for Myopia Development.Investigative ophthalmology & visual science · 2025Article
- Mendelian Randomization Studies of Myopia: Choosing the Right Summary Statistics.Investigative ophthalmology & visual science · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMyopia is a common eye disease, and the effect of allergic diseases on myopia is unclear. This study was to explore the causal relationship between allergic diseases and myopia risk through a two-sample Mendelian randomization (MR) analysis. MATERIALS AND
methodsGenetic variants related to allergic diseases (allergic conjunctivitis, atopic dermatitis, allergic rhinitis, and asthma) and immunoglobulin E and myopia were extracted from the MRC-IEU Open genome-wide association studies (GWAS) project. The results of MR were based on the inverse-variance weighted (IVW) analysis. The odds ratio (OR) and 95% confidence interval (CI) were used to report causal relationships.
resultsGenetically predicted asthma [IVW: OR = 1.233 (95% CI: 1.043-1.456), P = 0.0140] and higher immunoglobulin E levels [IVW: OR = 1.136 (95% CI: 1.020-1.265), P = 0.0207] increased the risk of myopia. There was no significant causal relationship between allergic conjunctivitis (IVW: P = 0.2916), atopic dermatitis (IVW: P = 0.3168), and allergic rhinitis (IVW: P = 0.8297) and risk of myopia. Further analysis revealed that the causal correlation of immunoglobulin E levels with myopia risk was caused by outliers.
conclusionsGenetically predicted asthma increased the risk of myopia.
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