Evidence map›Paper›PMID 40121338›Full record

ArticleScientific reports2025

Identification of RNA processing factor LSM5 as a new adverse biomarker in nasopharyngeal carcinoma.

Ting Lin, Linyu Deng, Siyu Liu, Yan Chen, Yinggang Tang, Fangliang Zhou, Guanghui Gong, Yingchun He

RetractedAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ting LinHunan Provincial Engineering Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases With Chinese Medicine and Visual Function Protection, Hunan University of Chinese Medicine, No. 300, Xuba Road, Hanpu Science and Education Park, Changsha, 410208, Hunan, People's Republic of China.
Linyu DengCollege of Acupuncture, Massage and Rehabilitation of Hunan University of Chinese Medicine, Changsha, 410208, Hunan, People's Republic of China.
Siyu LiuGraduate School of Hunan University of Chinese Medicine, Changsha, 410208, Hunan, People's Republic of China.
Yan ChenGraduate School of Hunan University of Chinese Medicine, Changsha, 410208, Hunan, People's Republic of China.
Yinggang TangGraduate School of Hunan University of Chinese Medicine, Changsha, 410208, Hunan, People's Republic of China.
Fangliang ZhouHunan Provincial Engineering Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases With Chinese Medicine and Visual Function Protection, Hunan University of Chinese Medicine, No. 300, Xuba Road, Hanpu Science and Education Park, Changsha, 410208, Hunan, People's Republic of China.
Guanghui GongDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China. gongguanghui@csu.edu.cn.ORCID http://orcid.org/0000-0003-4653-1248
Yingchun HeHunan Provincial Engineering Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases With Chinese Medicine and Visual Function Protection, Hunan University of Chinese Medicine, No. 300, Xuba Road, Hanpu Science and Education Park, Changsha, 410208, Hunan, People's Republic of China. heyingchun@hnucm.edu.cn.ORCID http://orcid.org/0000-0001-8723-160X

Funding

the Domestic First-Class Discipline Construction Project of Chinese Medicine of the Hunan University of Chinese Medicine 2022ZYX03the Domestic First-Class Discipline Construction Project of Chinese Medicine of the Hunan University of Chinese Medicine 2022ZYX22the Hunan Provincial Natural Science Foundation Project 2025JJ90022the National Natural Science Foundation of China 82405496the Project of the Hunan Provincial Department of Education 23B0355Work Station Guidance Project of Academician Liu Liang, Hunan University of Chinese Medicine 22YS001
6 · The paper itself

Abstract

Dysregulated RNA processing is crucial in nasopharyngeal carcinoma (NPC) progression. Our research aimed to evaluate the prognostic values of RNA-processing genes (RPGs) in NPC through bioinformatic analysis of the GSE12452 and GSE102349 datasets, identifying differentially expressed RNA-processing genes (DE-RPGs). A prognostic model was developed using univariate and multivariate Cox analysis, with effectiveness assessed by ROC analysis. The correlation between risk scores, immune characteristics, and chemotherapy sensitivity was also analyzed. Model gene expression was validated by RT-qPCR, Western Blot, and immunohistochemistry, alongside functional assays. Bioinformatics indicated that RNA binding motif protein 20 (RBM20) and LSM5 are prognostic RPGs, with the ROC curve confirming their predictive ability for survival. Significant differences in drug sensitivity were noted between high- and low-risk groups. Experimental validation showed LSM5 is overexpressed in NPC tissues, correlating with poorer prognosis, and its down-regulation inhibits cell proliferation and migration. Thus, LSM5 is identified as a new adverse biomarker in NPC, with implications for targeted therapy and prognosis improvement.

Indexed as

Biomarkers, TumorNasopharyngeal CarcinomaNasopharyngeal NeoplasmsRNA-Binding ProteinsCell Line, TumorCell MovementCell ProliferationComputational BiologyFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPrognosisBiomarkers, TumorRNA-Binding ProteinsLSM5Nasopharyngeal carcinomaPrognostic signatureRBM20RNA-processing genes

Identifiers

PMID40121338
PMCPMC11929837

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.