ArticleScientific reports2025
Advanced extraction of Glycyrrhiza glabra root extract using a combined ultrasonic and cold plasma reactor.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Mechanistic insights into sonication-assisted cold plasma treatments for improved microbial decontamination and quality maintenance in perishable foods.Ultrasonics sonochemistry · 2026Review
- Extraction, purification, structural characterization, bioactivities, and applications ofRSC advances · 2026Review
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5 authors.
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Abstract
Liquorice (Glycyrrhiza glabra L.) root extract has been used as a natural medicine and sweetener for a long time in many parts of the world. As a result, there has been a considerable emphasis on developing efficient and environmentally friendly methods for extracting bioactive components from Liquorice root. This work aims to examine extracting extract from Liquorice root using a combined ultrasonic-cold plasma reactor to elevate the extraction efficiency. Different parameters, including extraction time, ultrasonic power, and the argon-to-air ratio, were investigated using the Response Surface Methodology (RSM) and Box-Behnken design to raise extract quality. The total phenol and flavonoid content and antioxidant activity were calculated to evaluate this approach, and Glycyrrhizic acid content was quantified by HPLC (High-performance liquid chromatography). Results showed that combining ultrasonic-cold plasma extraction greatly raised the yield of extract and bioactive components compared to conventional maceration and single-method methods. Particularly, The content of total phenol 10.23, 15.96, and 13.29%, total flavonoid content 21.47, 22.19, and 42.41%, and Glycyrrhizic acid 10.84%, 12.38%, and 15.89% increased by ultrasonic, cold plasma, and combined ultrasonic-cold plasma technique, respectively, compared to the maceration technique. Optimization of different extraction techniques showed that the best extract quality came from a mix of ultrasonic power, plasma composition, and extraction time. This study demonstrates that the combined ultrasonic-cold plasma technique is effective and efficient, and this technology has the potential for a new extraction method to present a more sustainable and effective substitute for premium Liquorice extracts for medicinal and commercial uses.
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