ArticleNature communications2025
Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes.
Abstract read
In one paragraph
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Pharmacological manipulation of Sema4D by salvianolic acid A mitigates diabetic retinopathy via inhibiting PlexinB1/RhoA/ROCK/pMLC2 signaling cascade involved in endothelial dysfunction.Chinese medicine · 2026Article
- Proteolytic remodelling of the extracellular matrix by pericytes.The FEBS journal · 2026Review
- Smoking and Early Readmission After NVUGIB: Clinical and Mechanistic Considerations.Digestive diseases and sciences · 2026Article
- Myofibroblast lineage mapping and inhibiting subretinal fibrosis by targeting SMAD3 and MRTF pathways via microRNA-24 functional study.bioRxiv : the preprint server for biology · 2026Article
- DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age-Related Macular Degeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CD8+ T cell aging is associated with macular neovascularization area change in neovascular age-related macular degeneration: a prospective cohort study.BMC ophthalmology · 2026Article
- Artificial intelligence for precision therapeutics in age-related macular degeneration: current advances, challenges, and future directions.Frontiers in artificial intelligence · 2026Review
- The Convergent Immunopathogenesis of Cigarette Smoke Exposure: From Oxidative Stress to Epigenetic Reprogramming in Chronic Disease.International journal of molecular sciences · 2025Review
- Review
- The role of HMOX1-mediated ferroptosis in blue light-induced damage to retinal pigment epithelium.Scientific reports · 2025Article
- Causal associations between smoking and ocular diseases: a Mendelian randomization study.Advances in ophthalmology practice and researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Kai He *Department of Ophthalmology, Laboratory of Molecular Ophthalmology and Tianjin Key Laboratory of Ocular Trauma, Ministry of Education International Joint Laboratory of Ocular Diseases, Tianjin Institute of Eye Health and Eye Diseases, China-UK "Belt and Road" Ophthalmology Joint Laboratory, State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Xue Dong *Department of Ophthalmology, Laboratory of Molecular Ophthalmology and Tianjin Key Laboratory of Ocular Trauma, Ministry of Education International Joint Laboratory of Ocular Diseases, Tianjin Institute of Eye Health and Eye Diseases, China-UK "Belt and Road" Ophthalmology Joint Laboratory, State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Tianjing Yang *School of Medicine, Nankai University, Tianjin, China.
Ziqi LiDepartment of Ophthalmology, Laboratory of Molecular Ophthalmology and Tianjin Key Laboratory of Ocular Trauma, Ministry of Education International Joint Laboratory of Ocular Diseases, Tianjin Institute of Eye Health and Eye Diseases, China-UK "Belt and Road" Ophthalmology Joint Laboratory, State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Yuming LiuDepartment of Ophthalmology, Laboratory of Molecular Ophthalmology and Tianjin Key Laboratory of Ocular Trauma, Ministry of Education International Joint Laboratory of Ocular Diseases, Tianjin Institute of Eye Health and Eye Diseases, China-UK "Belt and Road" Ophthalmology Joint Laboratory, State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.ORCID http://orcid.org/0009-0001-3392-1362
Jing HeLaboratory of Vascular Biology and Organ Homeostasis, Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Meng WuDepartment of Ophthalmology, Laboratory of Molecular Ophthalmology and Tianjin Key Laboratory of Ocular Trauma, Ministry of Education International Joint Laboratory of Ocular Diseases, Tianjin Institute of Eye Health and Eye Diseases, China-UK "Belt and Road" Ophthalmology Joint Laboratory, State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Selena Wei-ZhangDepartment of Ophthalmology, Laboratory of Molecular Ophthalmology and Tianjin Key Laboratory of Ocular Trauma, Ministry of Education International Joint Laboratory of Ocular Diseases, Tianjin Institute of Eye Health and Eye Diseases, China-UK "Belt and Road" Ophthalmology Joint Laboratory, State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Parhat KaysarDepartment of Ophthalmology, Laboratory of Molecular Ophthalmology and Tianjin Key Laboratory of Ocular Trauma, Ministry of Education International Joint Laboratory of Ocular Diseases, Tianjin Institute of Eye Health and Eye Diseases, China-UK "Belt and Road" Ophthalmology Joint Laboratory, State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Bohao CuiDepartment of Ophthalmology, Laboratory of Molecular Ophthalmology and Tianjin Key Laboratory of Ocular Trauma, Ministry of Education International Joint Laboratory of Ocular Diseases, Tianjin Institute of Eye Health and Eye Diseases, China-UK "Belt and Road" Ophthalmology Joint Laboratory, State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Xueming YaoSchool of Medicine, Nankai University, Tianjin, China.
Li ZhangDepartment of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wei ZhouDepartment of Ophthalmology, Laboratory of Molecular Ophthalmology and Tianjin Key Laboratory of Ocular Trauma, Ministry of Education International Joint Laboratory of Ocular Diseases, Tianjin Institute of Eye Health and Eye Diseases, China-UK "Belt and Road" Ophthalmology Joint Laboratory, State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Heping XuThe Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0003-4000-931X
Jun WeiInstitute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.ORCID http://orcid.org/0000-0002-6769-847X
Qiang LiuDepartment of Neurology, Tianjin Neurological Institute, Tianjin Institute of Immunology, Tianjin Medical University General Hospital, Tianjin, China.ORCID http://orcid.org/0000-0002-6621-0591
Junhao HuLaboratory of Vascular Biology and Organ Homeostasis, Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China. jhhu@sioc.ac.cn.ORCID http://orcid.org/0000-0003-0699-1119
Xiaohong WangDepartment of Ophthalmology, Laboratory of Molecular Ophthalmology and Tianjin Key Laboratory of Ocular Trauma, Ministry of Education International Joint Laboratory of Ocular Diseases, Tianjin Institute of Eye Health and Eye Diseases, China-UK "Belt and Road" Ophthalmology Joint Laboratory, State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China. xiaohongwang@tmu.edu.cn.ORCID http://orcid.org/0000-0001-8628-243X
Hua YanDepartment of Ophthalmology, Laboratory of Molecular Ophthalmology and Tianjin Key Laboratory of Ocular Trauma, Ministry of Education International Joint Laboratory of Ocular Diseases, Tianjin Institute of Eye Health and Eye Diseases, China-UK "Belt and Road" Ophthalmology Joint Laboratory, State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China. zyyyanhua@tmu.edu.cn.ORCID http://orcid.org/0000-0002-7651-840X
Funding
National Natural Science Foundation of China (National Science Foundation of China) 82020108007National Natural Science Foundation of China (National Science Foundation of China) 82122018National Natural Science Foundation of China (National Science Foundation of China) 82330031Natural Science Foundation of Tianjin City (Natural Science Foundation of Tianjin) 23JCQNJC01290
Abstract
Age-related macular degeneration (AMD) is a prevalent neuroinflammation condition and the leading cause of irreversible blindness among the elderly population. Smoking significantly increases AMD risk, yet the mechanisms remain unclear. Here, we investigate the role of Sema4D-PlexinB1 axis in the progression of AMD, in which Sema4D-PlexinB1 is highly activated by smoking. Using patient-derived samples and mouse models, we discover that smoking increases the presence of Sema4D on the surface of CD8
Indexed as
Antigens, CDCell Adhesion Molecules, NeuronalChoroidal NeovascularizationMacular DegenerationNerve Tissue ProteinsPericytesSemaphorinsSmokingAgedAnimalsChemokine CXCL12ChoroidDisease Models, AnimalFemaleHumansMaleAntigens, CDCD100 antigenCell Adhesion Molecules, NeuronalChemokine CXCL12Nerve Tissue ProteinsPLXNB1 protein, humanPlxnb1 protein, mouseReceptors, Cell SurfaceReceptors, CXCR4Sema4d protein, mouseSemaphorins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.