Evidence map›Paper›PMID 40121127›Full record

Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2025

Loneliness, Self-Efficacy and Adaptive Coping: Mixed Methods Analysis of Mediation in a Peer Support Intervention for Depression.

Jin Hui Joo, Alice Xie, Namkee Choi, Joseph J Gallo, Joseph Locascio, Mingyue Ma, Ryan A Mace, Phyllis Solomon, Uma Khemraj

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jin Hui JooMassachusetts General Hospital (JHJ, AX, JL, RAM, UK), Harvard Medical School, Boston, MA. Electronic address: jhjoo@mgh.harvard.edu.
Alice XieMassachusetts General Hospital (JHJ, AX, JL, RAM, UK), Harvard Medical School, Boston, MA.
Namkee ChoiSteve Hicks School of Social Work (NC), University of Texas at Austin, Austin, TX.
Joseph J GalloBloomberg School of Public Health (JJG), Johns Hopkins University, Baltimore, MD.
Joseph LocascioMassachusetts General Hospital (JHJ, AX, JL, RAM, UK), Harvard Medical School, Boston, MA; Harvard Catalyst Biostatistical Group (JL), Massachusetts General Hospital, Boston, MA.
Mingyue MaChan School of Public Health (MM), Harvard University, Boston, MA.
Ryan A MaceMassachusetts General Hospital (JHJ, AX, JL, RAM, UK), Harvard Medical School, Boston, MA; Center for Health Outcomes and Interdisciplinary Research (RAM), Massachusetts General Hospital, Boston, MA.
Phyllis SolomonSchool of Social Policy & Practice (PS), University of Pennsylvania, Philadelphia, PA.
Uma KhemrajMassachusetts General Hospital (JHJ, AX, JL, RAM, UK), Harvard Medical School, Boston, MA.

Funding

Peer Enhanced Depression Care: Using Peer Mentors to Provide Self-Care Support to Low-Income and Minority Older AdultsR01MH123165 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI JOO, JIN HUI · 2019 to 2022
$2.4M
My Healthy Brain: a mindfulness-based lifestyle intervention to modify early risk of dementia in older adultsK23AG075257 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Ryan Andrew Mace · 2022 to 2026
$961k
NIA NIH HHS K23 AG075257NIMH NIH HHS R01 MH123165
6 · The paper itself

Abstract

objectiveWe assessed social connection, self-efficacy, and coping as mediators in a peer support intervention for depressed low-income and minoritized older adults.

methodsConvergent mixed methods analysis of data collected in an RCT with at-risk older adults (N = 149) comparing the effectiveness of PEERS, an 8-week peer support, self-care intervention on depression to telephone calls providing social interaction for the control group. Assessments occurred at baseline, postintervention, and every 3 months up to 12 months. Mediation effects of loneliness, self-efficacy, and coping were analyzed using longitudinal mixed effects modeling after z-score standardization, complemented by semi-structured interviews. We report results in regression coefficients, i.e. in standard deviation units.

resultsLoneliness had an indirect effect on depression in both intervention (-0.32 [95% CI: -0.48, -0.19]) and control groups (-0.16 [95% CI: -0.27, -0.04]). Self-efficacy had an indirect effect of -0.17 (95% CI: [-0.24, -0.05]) at postintervention and -0.20 (95% CI: [-0.30, -0.08]) at 12 months for the PEERS group. Adaptive coping had an indirect effect with -0.15 (95% CI: [-0.26, -0.06]) at postintervention and -0.15 (95% CI: [-0.32, -0.04]) at 12 months for the PEERS group, No evidence of mediation for self efficacy nor coping was found for the control group. Qualitative results indicated reduced loneliness, improved coping and behavior change among intervention participants. Control group participants reported social support from telephone calls but did not mention improved self-efficacy and coping skills.

conclusionsSocial engagement and peer support intervention have a common pathway, e.g. alleviation of loneliness in reducing depression, but the PEERS intervention can also decrease depression by improving self-efficacy and adaptive coping.

Indexed as

Adaptation, PsychologicalDepressionLonelinessPeer GroupSelf EfficacySocial SupportAgedAged, 80 and overFemaleHumansMaleMiddle AgedPovertyCopingDepressionLonelinessMediationMediation analysisPeer supportSelf-efficacy

Identifiers

PMID40121127
PMCPMC12085289

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.