Evidence map›Paper›PMID 40121061›Full record

GuidelineGastroenterology2025

AGA Living Clinical Practice Guideline on Computer-Aided Detection-Assisted Colonoscopy.

Shahnaz Sultan, Dennis L Shung, Jennifer M Kolb, Farid Foroutan, Cesare Hassan, Charles J Kahi, Peter S Liang, Theodore R Levin, Shazia Mehmood Siddique, Benjamin Lebwohl

Abstract readPractice GuidelineSystematic Review
In one paragraph

Guideline in Gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. How Does Artificial Intelligence-Assisted Endoscopy Impact Upper Gastrointestinal Screening?Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026
    Article
  6. Ethical and Legal Implications of Implementing AI in Gastrointestinal Endoscopy.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026
    Review
  7. Article
  8. Article
  9. World Endoscopy Organization Position Statements for Artificial Intelligence in Endoscopic Diagnosis of Gastric Epithelial Neoplasia.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Optimizing detection and resection of colorectal polyps.Translational gastroenterology and hepatology · 2026
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shahnaz SultanDivision of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, Minnesota; Minneapolis Veterans Affairs Healthcare System, Minneapolis, Minnesota.
Dennis L ShungDepartment of Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut.
Jennifer M KolbVatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California; Division of Gastroenterology, Hepatology and Parenteral Nutrition, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California.
Farid ForoutanMAGIC Evidence Ecosystem Foundation, Oslo, Norway; Ted Rogers Centre for Heart Research, University Health Network, Toronto, Ontario, Canada.
Cesare HassanIRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Charles J KahiDepartment of Gastroenterology, Indiana University Medical Center, Indianapolis, Indiana.
Peter S LiangDepartment of Medicine, Division of Gastroenterology and Hepatology, NYU Langone Health, New York, New York; Department of Medicine, Veterans Affairs New York Harbor Health Care System, New York, New York.
Theodore R LevinDivision of Research, Kaiser Permanente Northern California, Pleasanton, California; Department of Gastroenterology, Kaiser Permanente Walnut Creek, Walnut Creek, California.
Shazia Mehmood SiddiqueDivision of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Healthcare Improvement and Patient Safety, University of Pennsylvania, Philadelphia, Pennsylvania.
Benjamin LebwohlDepartment of Medicine, Columbia University Irving Medical Center, New York, New York; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.

Funding

Evaluation of Novel Technologies to Improve Clinical Management of Celiac Disease: The GLUTECH TrialU01DK136523 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Benjamin Lebwohl, Randi L. Wolf · 2023 to 2026
$5.7M
Longitudinal Adherence to Colorectal Cancer Screening in the VAK08CA230162 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIANG, PETER SHUANG · 2019 to 2023
$1.1M
Deep Learning Approaches to Risk Stratification in Acute Gastrointestinal BleedingK23DK125718 · NIDDK · YALE UNIVERSITY · PI SHUNG, DENNIS · 2021 to 2025
$969k
Evaluation of variability in care and outcomes for patients with gastrointestinal bleedingK08DK120902 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SIDDIQUE, SHAZIA MEHMOOD · 2020 to 2024
$851k
FDA HHS U01 FD008147NCI NIH HHS K08 CA230162NIDDK NIH HHS K08 DK120902NIDDK NIH HHS K23 DK125718NIDDK NIH HHS U01 DK136523
6 · The paper itself

Abstract

BACKGROUND &

aimsThis American Gastroenterological Association (AGA) guideline is intended to provide an overview of the evidence and support endoscopists and patients on the use of computer-aided detection (CADe) systems for the detection of colorectal polyps during colonoscopy.

methodsA multidisciplinary panel of content experts and guideline methodologists used the Grading of Recommendations Assessment, Development and Evaluation framework and relied on the following sources of evidence: (1) a systematic review examining the desirable and undesirable effects (ie, benefits and harms) of CADe-assisted colonoscopy, (2) a microsimulation study estimating the effects of CADe on longer-term patient-important outcomes, (3) a systematic search of evidence evaluating the values and preferences of patients undergoing colonoscopy, and (4) a systematic review of studies evaluating health care providers' trust in artificial intelligence technology in gastroenterology.

resultsThe panel reached the conclusion that no recommendation could be made for or against the use of CADe-assisted colonoscopy in light of very low certainty of evidence for the critical outcomes, desirable and undesirable (11 fewer colorectal cancers per 10,000 individuals and 2 fewer colorectal cancer deaths per 10,000 individuals), increased burden of more intensive surveillance colonoscopies (635 more per 10,000 individuals), and cost and resource implications. The panel acknowledged the 8% (95% CI, 6%-10%) increase in adenoma detection rate and 2% (95% CI, 0%-4%) increase in advanced adenoma and/or sessile serrated lesion detection rate.

conclusionsThis guideline highlights the close tradeoff between desirable and undesirable effects and the limitations in the current evidence to support a recommendation. The panel acknowledged the potential for CADe to continually improve as an iterative artificial intelligence application. Ongoing publications providing evidence for critical outcomes will help inform a future recommendation.

Indexed as

Colonic PolypsColonoscopyColorectal NeoplasmsDiagnosis, Computer-AssistedGastroenterologyArtificial IntelligenceEvidence-Based MedicineHumansPredictive Value of TestsSocieties, MedicalUnited StatesArtificial IntelligenceColonoscopyColorectal CancerComputer-Aided Detection

Identifiers

PMID40121061
PMCPMC12281637

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.