ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2025
Lung rehabilitation using xenogeneic cross-circulation does not lead to hyperacute rejection in a human lung transplantation model.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAccess to life-saving lung transplantation remains limited by a shortage of donor organs. We have previously described rehabilitation of discarded human donor lungs to a quality suitable for transplantation using cross-circulation of whole blood between xeno-support swine and human lungs. However, the immunologic implications of transplanting rehabilitated lungs remain unknown.
methodsHuman donor lungs declined for clinical transplantation (N = 5) and underwent xenogeneic cross-circulation (XC) for up to 12 hours. To model subsequent human transplantation, lungs were re-exposed to autologous human whole blood via normothermic ex vivo machine perfusion for up to 6 hours. Upon human blood re-exposure (HBR), lungs were evaluated for evidence of hyperacute rejection (HAR) through physiologic assessments and tissue analyses including histology, immunostaining, and flow cytometry.
resultsUpon HBR, lungs showed no significant change in physiologic function relative to the end of cross-circulation (PaO
conclusionsOur findings indicate that transient exposure of human donor lungs to XC does not result in HAR upon simulated human transplantation, representing an important step toward clinical translation of this donor organ rehabilitation platform.
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