Evidence map›Paper›PMID 40120583›Full record

ArticleCurrent biology : CB2025

The activation of INF2 by Piezo1/Ca

Neelakshi Kar, Alexa P Caruso, Nicos Prokopiou, Alleah Abrenica, Jeremy S Logue

Abstract read
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Amoeboid cancer cells at a glance.Journal of cell science · 2026
    Review
  5. Review
  6. Lipid Regulation of Mechanosensitive Ion Channels.International journal of molecular sciences · 2026
    Review
  7. Stress transmission towards the nucleus of the cell.Frontiers in cell and developmental biology · 2026
    Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Neelakshi KarDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA.
Alexa P CarusoDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA.
Nicos ProkopiouDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA.
Alleah AbrenicaDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA.
Jeremy S LogueDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA. Electronic address: loguej@mail.amc.edu.

Funding

Molecular Mechanisms of Confined Cell MigrationR35GM146588 · NIGMS · ALBANY MEDICAL COLLEGE · PI Jeremy S Logue · 2022 to 2026
$2.0M
NIGMS NIH HHS R35 GM146588
6 · The paper itself

Abstract

To invade tissues, cells may undergo a mesenchymal-to-amoeboid transition (MAT). However, the mechanisms regulating this transition are poorly defined. In melanoma cells, we demonstrate that intracellular [Ca

Indexed as

CalciumCell MovementForminsIon ChannelsCell Line, TumorHumansCalciumForminsIon ChannelsPIEZO1 protein, humanamoeboidblebcancercell migrationINF2mechanotransductionmetastasismicroenvironmentPiezo1ROCK2

Identifiers

PMID40120583
PMCPMC12014357

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.