Evidence map›Paper›PMID 40120017›Full record

ArticleJournal of autism and developmental disorders2026

Developmental Profiles of Young Children Referred for Concern for Autism Spectrum Disorder: DBPNet Study.

Nancy Roizen, Sandra Friedman, Douglas Vanderbilt, Jaclyn Cacia, Jill Fussell, Robin Hansen, Johannes Hofer, Georgio Sideridis, Ruth E K Stein, William Barbaresi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nancy RoizenDepartment of Pediatrics, Rainbow Babies and Children's Hospital, 10524 Euclid Ave Suite 3150, Cleveland, OH, 44106, USA. Nancy.roizen@uhhospitals.org.ORCID http://orcid.org/0000-0002-5699-9445
Sandra FriedmanDepartment of Pediatrics, University of Colorado School of Medicine/Children's Hospital Colorado, Aurora, CO, USA.
Douglas VanderbiltDepartment of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Jaclyn CaciaDepartment of Pediatrics, The Children's Hospital of Pediatrics, Philadelphia, PA, USA.
Jill FussellDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Robin HansenDepartment of Pediatrics, University of California, Davis, Sacramento, CA, USA.
Johannes HoferInstitute for Neurology of the Senses and Language, Hospital of St, John of God, Linz, Austria.
Georgio SideridisInternational Precision Child Health Partnership, Boston Children's Hospital, Boston, Massachusetts, USA.
Ruth E K SteinAlbert Einstein College of Medicine, Department of Pediatrics Bronx, Children's Hospital at Montefiore, NY, USA.
William BarbaresiDepartment of Pediatrics, Boston Children's Hospital, Boston, MA, USA.

Funding

HRSA HHS UT5MC42432
6 · The paper itself

Abstract

The aim of this study was to compare differences in cognitive, adaptive, and language function in young children referred for concerns for autism spectrum disorder (ASD) who are diagnosed with ASD vs those not diagnosed with ASD (no ASD). This prospective diagnostic study of 349 children < 6 years of age, with 250 diagnosed with ASD and 99 with no ASD, was conducted at 8 diagnostic centers. There were no differences in cognition between those diagnosed with ASD and those with no ASD. As compared to those with no ASD, children with ASD had significantly lower language and adaptive functioning. Children with no ASD had language and adaptive functioning similar to their cognitive function. Differences between developmental domains were also compared within the ASD and no ASD groups. There were no differences between any 2 areas of function in the no ASD group. However, there were significant differences within the ASD group, with cognitive function significantly higher than both language function and adaptive function. This study suggests that a discrepancy between adaptive and language skills beyond that expected based on cognitive function should heighten concern for ASD. Beyond the categorical diagnosis of ASD, it is important to assess all these developmental domains to develop comprehensive plans for interventions.

Indexed as

Adaptation, PsychologicalAutism Spectrum DisorderChild DevelopmentCognitionChild, PreschoolFemaleHumansInfantMaleProspective StudiesAdaptiveAutismCognitionDevelopmental profilesLanguageYoung children

Identifiers

PMID40120017
PMCPMC13391734

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.