Evidence map›Paper›PMID 40119996›Full record

ArticleClinical oral investigations2025

Efficacy of collagenated bone substitutes for bone regeneration in two-wall-damaged extraction sockets without barrier membranes.

Seungho Jeong, Franz J Strauss, Hae Jee Shin, Jin-Young Park, Jae-Kook Cha, Jung-Seok Lee

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Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Seungho Jeong *Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, South Korea.ORCID http://orcid.org/0009-0008-6997-8310
Franz J Strauss *Clinic of Reconstructive Dentistry, Center for Dental Medicine, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-5832-7327
Hae Jee ShinDepartment of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, South Korea.ORCID http://orcid.org/0009-0007-4250-4660
Jin-Young ParkDepartment of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, South Korea.ORCID http://orcid.org/0000-0002-6408-1618
Jae-Kook ChaDepartment of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, South Korea.ORCID http://orcid.org/0000-0002-6906-7209
Jung-Seok LeeDepartment of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, South Korea. cooldds@gmail.com.ORCID http://orcid.org/0000-0003-1276-5978

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate ridge dimensional changes following alveolar ridge augmentation in two-wall-damaged extraction sockets without a barrier membrane, using two types of collagenated bone substitutes i. cross-linked (CL-CB) and ii. non-cross-linked (NCL-CB). MATERIALS AND

methodsTwo-wall defects were created in mandibles of seven beagle dogs and treated in three groups: (i) no grafting (control), (ii) sockets filled with NCL-CB, and (iii) sockets filled with CL-CB. No barrier membrane was used. One animal was sacrificed after 1 week of healing for tissue assessments (n = 1), and the other six were sacrificed after 8 weeks of healing for microcomputed tomography (micro-CT) and histological analyses (n = 6).

resultsCompared to unextracted sites, radiographic analysis revealed that the alveolar ridge dimension decreased to 83.29 ± 24.96% in group NCL-CB, 73.46 ± 16.59% in group CL-CB and 55.41 ± 12.95% in non-grafted sites (intergroup p = 0.062). Histological analysis showed that compared to baseline values the ridge area decreased to 68.75 ± 14.20% in the non-grafted group, 79.88 ± 20.05% in the NCL-CB group and 76.10 ± 21.09% in the CL-CB group with no significant differences between the groups (p > 0.05). Qualitative histological analyses revealed significantly less mineralized tissue in both test groups, amounting to 25.28 ± 10.40% in group NCL-CB, 29.86 ± 12.04% in group CL-CB, and 67.15 ± 14.35% in non-grafted sites (intergroup p < 0.05).

conclusionThe efficacy of alveolar ridge augmentation using either cross-linked or non-cross-linked collagenated bone substitutes alone might be limited in severely damaged sockets such as those with two-wall defects. CLINICAL RELEVANCE: In situations where sockets are extensively damaged, like those with two-wall defects, relying solely on soft-type bone block substitutes without a barrier membrane may not provide sufficient bone regeneration. This study highlights the importance of considering additional regenerative strategies, such as the use of barrier membranes, to enhance clinical outcomes.

Indexed as

Alveolar Ridge AugmentationBone RegenerationBone SubstitutesCollagenTooth SocketAnimalsDogsMandibleMembranes, ArtificialTooth ExtractionX-Ray MicrotomographyBone SubstitutesCollagenMembranes, ArtificialAnimal modelBone regenerationBone substitutesTooth extraction

Identifiers

PMID40119996

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.