Evidence map›Paper›PMID 40119920›Full record

ArticlePflugers Archiv : European journal of physiology2025

Intrinsic responses to hypoxia and hypercapnia of neurons in the cardiorespiratory center of the ventral medulla of newborn rats.

Hiroshi Onimaru, Yui Koyanagi, Kamon Iigaya, Keiko Ikeda, Masahiko Izumizaki

Abstract read
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In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The effects of glucagon-like peptide-1 receptor agonists on sympathetic neuron activity.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hiroshi OnimaruDepartment of Physiology, Showa University School of Medicine, Tokyo, 142-8555, Japan. oni@med.showa-u.ac.jp.
Yui KoyanagiDepartment of Physiology, Showa University School of Medicine, Tokyo, 142-8555, Japan.
Kamon IigayaDepartment of Physiology, Showa University School of Medicine, Tokyo, 142-8555, Japan.
Keiko IkedaDepartment of Oral Physiology, Showa University School of Dentistry, Tokyo, Japan.
Masahiko IzumizakiDepartment of Physiology, Showa University School of Medicine, Tokyo, 142-8555, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rostral ventrolateral medulla (RVLM) includes a variety of neurons essential for cardiorespiratory control. Although some of these neurons are thought to be intrinsically sensitive to hypercapnia and/or hypoxia, relationships between types of neurons and responses to hypoxia and/or hypercapnia are not well understood. Tyrosine hydroxylase (TH) is one of the cell-type markers of the RVLM neurons. Here, we report effects of hypoxia and hypercapnia on TH-positive or -negative neurons in the RVLM of newborn rats. Brainstem-spinal cord preparations were isolated from 0-3-day-old Wistar rats and superfused with artificial cerebrospinal fluid equilibrated with 95% O

Indexed as

HypercapniaHypoxiaMedulla OblongataNeuronsRespiratory CenterAnimalsAnimals, NewbornMembrane PotentialsRatsRats, WistarTyrosine 3-MonooxygenaseTyrosine 3-MonooxygenaseBrainstem-spinal cordC1 adrenergic neuronsHypercapniaHypoxiaNewborn ratRespiratory neurons

Identifiers

PMID40119920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.